Novel forms of neurofascin 155 in the central nervous system: alterations in paranodal disruption models and multiple sclerosis.

Brain : a Journal of Neurology
A D PomicterJ L Dupree

Abstract

Stability of the myelin-axon unit is achieved, at least in part, by specialized paranodal junctions comprised of the neuronal heterocomplex of contactin and contactin-associated protein and the myelin protein neurofascin 155. In multiple sclerosis, normal distribution of these proteins is altered, resulting in the loss of the insulating myelin and consequently causing axonal dysfunction. Previously, this laboratory reported that mice lacking the myelin-enriched lipid sulphatide are characterized by a progressive deterioration of the paranodal structure. Here, it is shown that this deterioration is preceded by significant loss of neurofascin 155 clustering at the myelin paranode. Interestingly, prolonged electrophoretic separation revealed the existence of two neurofascin 155 bands, neurofascin 155 high and neurofascin 155 low, which are readily observed following N-linked deglycosylation. Neurofascin 155 high is observed at 7 days of age and reaches peak expression at one month of age, while neurofascin 155 low is first observed at 14 days of age and constantly increases until 5 months of age. Studies using conditional neurofascin knockout mice indicated that neurofascin 155 high and neurofascin 155 low are products of the neur...Continue Reading

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Citations

Apr 28, 2010·Journal of Cardiovascular Pharmacology·Wing Tak WongYu Huang
May 25, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Daniel M Blumenthal, Mark S Gold
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Dec 2, 2015·Neurodegenerative Disease Management·Jae Young LeeSteven Petratos
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Jul 16, 2016·Journal of Neurochemistry·Juan Pablo PalaviciniXianlin Han
Oct 22, 2016·Neuroscience Research·Ryan B GriggsKeiichiro Susuki
Mar 15, 2019·The Journal of Clinical Investigation·Constance MansoJérôme J Devaux

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