Novel function of scutellarin in inhibiting cell proliferation and inducing cell apoptosis of human Burkitt lymphoma Namalwa cells

Leukemia & Lymphoma
Yizhong FengQuansheng Zhou

Abstract

Anti-lymphoma therapy continues to present a major challenge. Even though cytotoxic therapy, immunotherapy and molecularly targeted therapy have been used in the clinic to treat the disease, effective anti-lymphoma drugs are still needed. In this study, we explored novel anti-lymphoma agents and found that scutellarin, an active component of a traditional Chinese medicinal herb Erigeron breviscapus, executed an anti-lymphoma effect. Scutellarin diminished the proliferation of B-lymphoma Namalwa cells in vitro and inhibited lymphoma growth in Namalwa cell-xenotransplanted mice without obvious toxicity. A mechanism study showed that scutellarin at doses of less than 10 μM induced cell cycle arrest at G0/G1 transition without the induction of cell apoptosis, which was accompanied by down-regulation of cyclin D1 and CDK4 expression. In contrast, scutellarin at concentrations of 15 μM or above promoted Namalwa cell apoptosis, which was partially associated with the activation of caspases. These results suggest that scutellarin is a new potential anti-lymphoma candidate.

References

Feb 15, 2001·Current Medicinal Chemistry·J A MantheyN Guthrie
Jul 19, 2005·Biochemical and Biophysical Research Communications·Gao-Hong ZhangYong-Tang Zheng
May 23, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Xiaoyan ChenDafang Zhong
Jul 24, 2007·Trends in Molecular Medicine·Thomas EfferthBernd Kaina
Feb 5, 2008·Methods : a Companion to Methods in Enzymology·Quansheng ZhouPaul Schimmel
Oct 3, 2008·Cancer Letters·Xiao-shan LiuYing-mu Cai
Dec 4, 2008·The American Journal of Chinese Medicine·Min WangYun Qi
Oct 20, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Chong-Zhi WangChun-Su Yuan
Dec 17, 2009·Nature Structural & Molecular Biology·Quansheng ZhouXiang-Lei Yang
Jun 16, 2010·Anti-cancer Agents in Medicinal Chemistry·Zhen-Feng Chen, Hong Liang
Jan 26, 2011·Histopathology·Eve Roman, Alexandra G Smith
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hendrik NogaiGeorg Lenz
Jun 11, 2011·Best Practice & Research. Clinical Haematology·Tom van Meerten, Anton Hagenbeek
Jun 11, 2011·Clinical Lymphoma, Myeloma & Leukemia·Stephanie J Martin, Madeleine Duvic
Jul 19, 2011·The Journal of Pharmacology and Experimental Therapeutics·Anliang DongMingyao Liu

❮ Previous
Next ❯

Citations

May 8, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yong-Long HanCheng Guo
Nov 12, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaohua DuWeimin Yang
Feb 24, 2015·Journal of Ethnopharmacology·Chengwei NiuZhengtao Wang
Feb 13, 2018·The American Journal of Chinese Medicine·Sebastian ChledzikJolanta Nazaruk
Jul 15, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Katrin Sak, Hele Everaus
Dec 29, 2020·Frontiers in Pharmacology·Yiyu WangShaofang Lin
May 2, 2017·European Journal of Medicinal Chemistry·Tong HanHuiming Hua
Mar 12, 2021·The American Journal of Chinese Medicine·Liu-Lin XiongXin-Fu Zhou
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wenting DengJinlian Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis