Abstract
Anti-lymphoma therapy continues to present a major challenge. Even though cytotoxic therapy, immunotherapy and molecularly targeted therapy have been used in the clinic to treat the disease, effective anti-lymphoma drugs are still needed. In this study, we explored novel anti-lymphoma agents and found that scutellarin, an active component of a traditional Chinese medicinal herb Erigeron breviscapus, executed an anti-lymphoma effect. Scutellarin diminished the proliferation of B-lymphoma Namalwa cells in vitro and inhibited lymphoma growth in Namalwa cell-xenotransplanted mice without obvious toxicity. A mechanism study showed that scutellarin at doses of less than 10 μM induced cell cycle arrest at G0/G1 transition without the induction of cell apoptosis, which was accompanied by down-regulation of cyclin D1 and CDK4 expression. In contrast, scutellarin at concentrations of 15 μM or above promoted Namalwa cell apoptosis, which was partially associated with the activation of caspases. These results suggest that scutellarin is a new potential anti-lymphoma candidate.
References
Feb 15, 2001·Current Medicinal Chemistry·J A MantheyN Guthrie
Jun 5, 2003·Fitoterapia·H LiuH B Xu
Jul 19, 2005·Biochemical and Biophysical Research Communications·Gao-Hong ZhangYong-Tang Zheng
May 23, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Xiaoyan ChenDafang Zhong
Jul 24, 2007·Trends in Molecular Medicine·Thomas EfferthBernd Kaina
Feb 5, 2008·Methods : a Companion to Methods in Enzymology·Quansheng ZhouPaul Schimmel
Oct 3, 2008·Cancer Letters·Xiao-shan LiuYing-mu Cai
Dec 4, 2008·The American Journal of Chinese Medicine·Min WangYun Qi
May 16, 2009·Phytotherapy Research : PTR·Dan WuWei-Xi Tian
Oct 20, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Chong-Zhi WangChun-Su Yuan
Dec 17, 2009·Nature Structural & Molecular Biology·Quansheng ZhouXiang-Lei Yang
Jun 16, 2010·Anti-cancer Agents in Medicinal Chemistry·Zhen-Feng Chen, Hong Liang
Nov 3, 2010·The Oncologist·Marco TuccoriMario Petrini
Nov 6, 2010·Journal of Cellular Biochemistry·Libin WeiQinglong Guo
Jan 26, 2011·Histopathology·Eve Roman, Alexandra G Smith
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hendrik NogaiGeorg Lenz
Apr 16, 2011·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Wei LiuQinglong Guo
Jun 11, 2011·Best Practice & Research. Clinical Haematology·Tom van Meerten, Anton Hagenbeek
Jun 11, 2011·Clinical Lymphoma, Myeloma & Leukemia·Stephanie J Martin, Madeleine Duvic
Jul 19, 2011·The Journal of Pharmacology and Experimental Therapeutics·Anliang DongMingyao Liu
Dec 22, 2011·Leukemia & Lymphoma·Sean WarschIzidore S Lossos
Citations
May 23, 2013·Anti-cancer Drugs·Ruifang LiuQuansheng Zhou
May 8, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yong-Long HanCheng Guo
Jan 26, 2016·Cancer Letters·Yinghui HuangFengtian He
Feb 5, 2013·Toxicology Letters·Zhifei CaoQuansheng Zhou
Nov 6, 2012·Toxicology Letters·Meimei BaoQuansheng Zhou
Aug 9, 2015·Toxicology and Applied Pharmacology·Ping YangQuansheng Zhou
Nov 12, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaohua DuWeimin Yang
Feb 24, 2015·Journal of Ethnopharmacology·Chengwei NiuZhengtao Wang
Apr 23, 2016·Neuromolecular Medicine·Yun YuanEng-Ang Ling
May 26, 2016·Biochemical and Biophysical Research Communications·Nana ZhengQuansheng Zhou
Feb 13, 2018·The American Journal of Chinese Medicine·Sebastian ChledzikJolanta Nazaruk
Jan 23, 2019·Thoracic Cancer·Pikun CaoYuliang Li
Nov 26, 2015·Anti-cancer Drugs·Jun HeZhifei Cao
Mar 28, 2019·BioMed Research International·Xiu-Ying HeTing-Hua Wang
Apr 3, 2013·International Journal of Oncology·Haixia LiJinhua Zheng
Jul 15, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Katrin Sak, Hele Everaus
Jul 3, 2018·Frontiers in Pharmacology·Juan NieYu-Cui Li
Apr 1, 2020·Chinese Medicine·Liu-Lin XiongTing-Hua Wang
Dec 31, 2016·Molecular Medicine Reports·Ning YangYanqiao Zhang
Dec 29, 2020·Frontiers in Pharmacology·Yiyu WangShaofang Lin
May 2, 2017·European Journal of Medicinal Chemistry·Tong HanHuiming Hua
Mar 12, 2021·The American Journal of Chinese Medicine·Liu-Lin XiongXin-Fu Zhou
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wenting DengJinlian Chen
Aug 3, 2021·Drug Delivery·Xinran WangShouying Du
Dec 19, 2020·Current Drug Metabolism·Hua FanJia-Yi Cheng