Novel Functionalized Selenium Nanoparticles for Enhanced Anti-Hepatocarcinoma Activity In vitro

Nanoscale Research Letters
Yu XiaFeiyue Xing

Abstract

Selenium nanoparticles loaded with an anticancer molecule offer a new strategy for cancer treatment. In the current study, anisomycin-loaded functionalized selenium nanoparticles (SeNPs@Am) have been made by conjugating anisomycin to the surface of selenium nanoparticles to improve anticancer efficacy. The prepared nanoparticles were fully characterized by transmission electronic microscopy, energy dispersive X-ray spectroscopy, Fourier-transformed infrared spectroscopy, and X-ray photoelectron spectroscopy. The results showed that anisomycin was successfully conjugated with selenium nanoparticles. The size of particles could be effectively regulated through altering the reaction concentrations of sodium selenite and anisomycin. The SeNPs@Am particles (56 nm) exhibited the greatest capacity for cellular uptake. The further study showed that SeNPs@Am entered human hepatocellular carcinoma HepG2 cells in a dose or time-dependent manner via macropinocytosis and clathrin-mediated endocytosis pathways. SeNPs@Am significantly inhibited HepG2 cell proliferation with the low cytotoxicity against normal cells, and dramatically precluded the aggression and migration of HepG2 cells. It also arrested the cell cycle progression at the G0/G1...Continue Reading

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Citations

Aug 31, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Jianjun ZouDonglan Huang
Sep 23, 2018·Biointerphases·Victoria le Ching TanKate Fox
Feb 12, 2021·Frontiers in Bioengineering and Biotechnology·Nenad FilipovićMagdalena M Stevanović
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olga TsivilevaAnastasiya Ivanova
Jul 17, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Mohamed Fawzi KabilIbrahim M El-Sherbiny

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Methods Mentioned

BETA
transmission electron microscopy
X-ray
infrared spectrometry
flow cytometry
Protein Assay
Fluorescence
Flow

Software Mentioned

SPSS
CellQuest

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