Novel genetic alterations and their impact on target therapy response in head and neck squamous cell carcinoma

Cancer Management and Research
Xiaohua JiangMang Xiao

Abstract

Head and neck squamous cell carcinoma (HNSCC) is highly variable by tumor site, histologic type, molecular characteristics, and clinical outcome. During recent years, emerging targeted therapies have been focused on driver genes. HNSCC involves several genetic alterations, such as co-occurrence, multiple feedback loops, and cross-talk communications. These different kinds of genetic alterations interact with each other and mediate targeted therapy response. In the current review, it is emphasized that future treatment strategy in HNSCC will not solely be based on "synthetic lethality" approaches directed against overactivated genes. More importantly, biologic, genetic, and epigenetic alterations of HNSCC will be taken into consideration to guide the therapy. The emerging genetic alterations in HNSCC and its effect on targeted therapy response are discussed in detail. Hopefully, novel combination regimens for the treatment of HNSCC can be developed.

Citations

Nov 13, 2020·Cancer Biotherapy & Radiopharmaceuticals·Guo-Sheng LiHong-Yu Wei
Jan 19, 2021·Computational and Mathematical Methods in Medicine·Cai YangJuan Li
Feb 13, 2021·International Journal of Molecular Sciences·Giuseppe RivaValentina Dell'Oste
Jul 25, 2021·Cancers·Farzaneh Kordbacheh, Camile S Farah
Aug 4, 2021·International Journal of Oral Science·Areeg ElmusratiCun-Yu Wang

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