Novel glomerular lipoprotein deposits associated with apolipoprotein E2 homozygosity

Kidney International
M SakatsumeF Gejyo

Abstract

Hyperlipoproteinemia is occasionally associated with severe glomerular injury caused by abnormal accumulation of lipid in glomeruli, which occurs in conditions such as lipoprotein glomerulopathy (LPG). This study investigates the cases of two siblings with homozygous apolipoprotein (apo) E2 who show unique histologic features, massive proteinuria, and dysbetalipoproteinemia. Histologic studies were performed using renal biopsy specimens. Plasma lipoproteins were extensively characterized. The exons of the apo E genes were sequenced to avoid missing any mutations. Histologically, the siblings' condition resembled LPG by light microscopy studies. Electron microscopy studies revealed large lipoid deposits in the paramesangium, subendothelium, and subepithelium of the glomeruli, which were different from LPG in terms of not forming the layered structure resembling a fingerprint even in large lipoprotein thrombi, and mesangial foam cells. Immunohistochemically, the lipoid deposits contained apo E and apo B. These patients did not have either diabetic nephropathy or other known forms of glomerulonephritis. The sequence of exons of the apo E genes revealed homozygosity for apo E2 in both cases. The extensive lipoprotein deposition in ...Continue Reading

References

Mar 15, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·T Nagasaki, Y Akanuma
May 11, 1991·Lancet·P R WenhamG Blandell
Mar 1, 1990·The Tohoku Journal of Experimental Medicine·T Miida
Feb 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T SaitoH Sakaguchi
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·Y K PaikJ M Taylor
Jul 1, 1987·Human Pathology·T Faraggiana, J Churg
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A MeyrierB Mougenot
Dec 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P ZhangG Gallo
Jan 1, 1993·American Journal of Nephrology·T SaitoH Sakaguchi
Oct 1, 1995·Journal of the American Society of Nephrology : JASN·D EllisJ R Diamond
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M A Mansell
Mar 1, 1997·The Tohoku Journal of Experimental Medicine·T Saito
May 1, 1997·Journal of the American Society of Nephrology : JASN·S OikawaJ Sasaki
May 1, 1997·Journal of the American Society of Nephrology : JASN·F E Karet, R P Lifton
Jan 20, 1999·Kidney International·N H GarcíaJ L Garvin
Jul 15, 1999·Journal of the American Society of Nephrology : JASN·T MiyataK Kurokawa
Jul 21, 1999·Kidney International. Supplement·H OdaM Yamakido
Jul 21, 1999·Kidney International. Supplement·T SaitoJ Sasaki
Oct 26, 1999·Nephron·N YoriokaM Yamakido
Sep 1, 1955·The Journal of Clinical Investigation·R J HAVELJ H BRAGDON

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Citations

Jul 20, 2002·Free Radical Biology & Medicine·Ramón Rodrigo, Gonzalo Rivera
Mar 13, 2003·Kidney International·Maurizio BruschiGian Marco Ghiggeri
Jan 5, 2007·Journal of Medicinal Food·Devinder SinghKanwaljit Chopra
May 1, 2002·Current Opinion in Nephrology and Hypertension·Meena Sahadevan, Bertram L Kasiske
Apr 6, 2011·Current Opinion in Lipidology·Vasilis Tsimihodimos, Moses Elisaf
Apr 12, 2013·SpringerPlus·Jennifer MadeoFrieri Marianne
Feb 18, 2011·Journal of Atherosclerosis and Thrombosis·Asuka MitaniTaku Yamamura
Apr 7, 2011·Journal of Atherosclerosis and Thrombosis·Takehiko TokuraNaoki Kashihara
Jan 11, 2014·Critical Reviews in Clinical Laboratory Sciences·A D MaraisD J Blom
Mar 6, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mikito HayakawaAkira Yamada
Jan 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Takao SaitoShinichi Oikawa
Jan 30, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Evagelos LiberopoulosMoses Elisaf
Dec 29, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Ramón Rodrigo, Cleofina Bosco
Oct 30, 2014·Frontiers in Endocrinology·Sandra MerscherArmando J Mendez
Aug 5, 2009·Toxicology and Industrial Health·D LoruM A Dessì
Dec 26, 2019·Kidney International·Takao SaitoEri Muso
Sep 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Chao-Fu ChangWu-Chang Yang
Jun 16, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kirk FosterM Barry Stokes
Jul 31, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Madhuri RamakrishnanDiane M Cibrik

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