PMID: 2121530Oct 1, 1990Paper

Novel GTP-binding proteins in plasma membranes and zymogen granule membranes from rat pancreas and in pancreatic AR 4-2J cell membranes

FEBS Letters
M LambertJ Christophe

Abstract

Photoaffinity labelling with [alpha-32P]GTP allowed to detect a 54 kDa GTP-binding protein in rat pancreatic plasma membranes and in pancreatic AR 4-2J cell membranes. Like the 42 and 48 kDa Gs alpha subunits and the 41 kDa Gi alpha subunit, this protein was absent from zymogen granule membranes. Contrastingly, a new 28 kDa GTP-binding protein (detected by [alpha-32P]GTP binding on immobilized proteins) and a 25 kDa protein (ADP-ribosylated by botulinum toxin D) were found in all three membrane preparations. This is to our knowledge the first report on GTP-binding proteins in zymogen granule membranes.

References

Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S K Nigam
Oct 1, 1989·Trends in Pharmacological Sciences·K Aktories, A Hall
Oct 1, 1989·Trends in Biochemical Sciences·R D Burgoyne
Jul 15, 1987·The Biochemical Journal·R P Bhullar, R J Haslam

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Citations

Aug 10, 1992·Biochimica Et Biophysica Acta·K VerheydenG P Mannaerts
Nov 22, 1996·The Journal of Biological Chemistry·M JinG E Palade
May 31, 1991·Biochemical and Biophysical Research Communications·R P RubinS G Laychock
Jan 31, 1991·Biochemical and Biophysical Research Communications·P J Padfield, J D Jamieson
Apr 15, 1992·Biochemical and Biophysical Research Communications·K GrosfilsJ P Dehaye

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