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Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses in Vitro and in Humanized Mice

Antimicrobial Agents and Chemotherapy

Nov 11, 2019

Franck AmblardRaymond Felix Schinazi

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Abstract

Hepatitis B virus (HBV) affects an estimated 250 million chronic carriers worldwide. Though several vaccines exist, they are ineffective for those already infected. HBV persists due to the formation of covalently-closed circular DNA (cccDNA) - the viral minichromosome - in the nucleus o...read more

Mentioned in this Paper

Antigens, Viral
Cell Nucleus
DNA
DNA, Circular
Genes, Viral
Hepatitis B Virus
Laboratory mice
Vaccines
Nucleocapsid
Hepatocyte
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Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses in Vitro and in Humanized Mice

Antimicrobial Agents and Chemotherapy

Nov 11, 2019

Franck AmblardRaymond Felix Schinazi

PMID: 31712213

DOI: 10.1128/aac.01701-19

Abstract

Hepatitis B virus (HBV) affects an estimated 250 million chronic carriers worldwide. Though several vaccines exist, they are ineffective for those already infected. HBV persists due to the formation of covalently-closed circular DNA (cccDNA) - the viral minichromosome - in the nucleus o...read more

Mentioned in this Paper

Antigens, Viral
Cell Nucleus
DNA
DNA, Circular
Genes, Viral

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