Novel human-derived extracellular matrix induces in vitro and in vivo vascularization and inhibits fibrosis

Biomaterials
Marc C MoorePeter S McFetridge

Abstract

The inability to vascularize engineered organs and revascularize areas of infarction has been a major roadblock to delivering successful regenerative medicine therapies to the clinic. These investigations detail an isolated human extracellular matrix derived from the placenta (hPM) that induces vasculogenesis in vitro and angiogenesis in vivo within bioengineered tissues, with significant immune reductive properties. Compositional analysis showed ECM components (fibrinogen, laminin), angiogenic cytokines (angiogenin, FGF), and immune-related cytokines (annexins, DEFA1) in near physiological ratios. Gene expression profiles of endothelial cells seeded onto the matrix displayed upregulation of angiogenic genes (TGFB1, VEGFA), remodeling genes (MMP9, LAMA5) and vascular development genes (HAND2, LECT1). Angiogenic networks displayed a time dependent stability in comparison to current in vitro approaches that degrade rapidly. In vivo, matrix-dosed bioscaffolds showed enhanced angiogenesis and significantly reduced fibrosis in comparison to current angiogenic biomaterials. Implementation of this human placenta derived extracellular matrix provides an alternative to Matrigel and, due to its human derivation, its development may have ...Continue Reading

References

Oct 7, 1991·Journal of Theoretical Biology·C L Stokes, D A Lauffenburger
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R MontesanoL Orci
Jun 1, 1996·The Journal of Surgical Research·M D HariawalaJ F Symes
Mar 1, 1997·American Journal of Ophthalmology·S H Lee, S C Tseng
Apr 17, 1997·Nature·W Risau
Nov 14, 1997·Nature Medicine·R K JainF Yuan
Mar 31, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K J O'ByrneA L Harris
Jul 12, 2001·Annual Review of Biomedical Engineering·R M Nerem, D Seliktar
Sep 19, 2001·The Journal of Clinical Investigation·M FebbraioR L Silverstein
Jun 27, 2002·Seminars in Cancer Biology·Manuel PatarroyoIsmo Virtanen
Jul 18, 2002·Nature Reviews. Drug Discovery·Massimo CristofanilliGabriel N Hortobagyi
Jan 1, 2003·Clinical Chemistry·Robert AuerbachNasim Akhtar
Jan 23, 2003·Molecular Aspects of Medicine·Peter H Burri, Valentin Djonov
Mar 20, 2003·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Haymo KurzValentin G Djonov
Jun 5, 2003·Nature Reviews. Cancer·Raghu Kalluri
Oct 24, 2003·Cell and Tissue Research·Valentin DjonovPeter H Burri
Nov 25, 2003·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Andreas H ZischJeffrey A Hubbell
Sep 24, 2004·International Journal of Experimental Pathology·Carolyn A StatonClaire E Lewis
Jun 21, 2005·Journal of Cellular and Molecular Medicine·Joyce E Rundhaug
Jun 23, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Joel DanielPeter S McFetridge
Jun 25, 2005·Seminars in Cancer Biology·Hynda K Kleinman, George R Martin
Sep 14, 2006·Tissue Engineering·Matthias W LaschkeMichael D Menger
Feb 3, 2007·Tissue Engineering·Cheng Zhe JinByoung-Hyun Min
May 6, 2008·Tissue Engineering. Part B, Reviews·Zerina Lokmic, Geraldine M Mitchell
May 12, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mark S WarrenKerry J Koller
May 22, 2009·Nature Materials·Elsie S PlaceMolly M Stevens

❮ Previous
Next ❯

Citations

Feb 13, 2016·Drug Delivery and Translational Research·Sarah TonelloPeter S McFetridge
Oct 30, 2016·Trends in Biotechnology·Sandra HauserJens Pietzsch
Mar 16, 2017·The Journal of Investigative Dermatology·Francesca CalcaterraSilvia Della Bella
Oct 3, 2018·Biofabrication·Ju Young ParkDong-Woo Cho
Aug 8, 2017·Advanced Healthcare Materials·Marc C MoorePeter S McFetridge
Dec 3, 2017·In Vitro Cellular & Developmental Biology. Animal·Joseph S ZakhariStuart K Williams
Apr 5, 2017·Bio-medical Materials and Engineering·Pan DanPatrick Menu
May 2, 2018·International Journal of Molecular Sciences·Mario Enrique Alvarèz FallasMichela Pozzobon
Jan 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Arun Prabhu RameshbabuSantanu Dhara
Oct 28, 2020·Connective Tissue Research·Carla Maria F CarvalhoSonja E Lobo
Jun 8, 2021·ACS Biomaterials Science & Engineering·Laura P FrazãoNuno M Neves
Aug 8, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiufang LiMingzhong Li
Nov 10, 2021·Tissue Engineering. Part C, Methods·Johannes HackethalAndreas Herbert Teuschl
Oct 30, 2021·Tissue Engineering. Part C, Methods·Johannes HackethalAndreas Herbert Teuschl-Woller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Xingang WangChunmao Han
© 2022 Meta ULC. All rights reserved