Novel Human-like Influenza A Viruses Circulate in Swine in Mexico and Chile

PLoS Currents
Martha I NelsonJulio Norambuena

Abstract

Further understanding of the genetic diversity and evolution of influenza A viruses circulating in swine (IAV-S) is important for the development of effective vaccines and our knowledge of pandemic threats. Until recently, very little was known of IAV-S diversity in Latin America, owing to a lack of surveillance. To address this gap, we sequenced and conducted a phylogenetic analysis of 69 hemagglutinin (HA) sequences from IAV-S isolates collected in swine in Mexico and Chile during 2010-2014, including the H1N1, H1N2, and H3N2 subtypes. Our analysis identified multiple IAV-S lineages that appear to have been circulating undetected in swine for decades, including four novel IAV-S lineages of human seasonal virus origin that have not been previously identified in any swine populations globally. We also found evidence of repeated introductions of pandemic H1N1 viruses from humans into swine in Mexico and Chile since 2009, and incursions of H1 and H3 viruses from North American swine into Mexico. Overall, our findings indicate that at least 12 genetically distinct HA lineages circulate in Latin American swine herds, only two of which have been found in North American swine herds. Human-to-swine transmission, spatial migration via ...Continue Reading

Citations

Apr 27, 2016·ELife·Nicola S LewisAmy L Vincent
Jun 29, 2016·ELife·Ignacio MenaAdolfo García-Sastre
May 12, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Kerry R Leedom LarsonGregory C Gray
Aug 21, 2018·Transboundary and Emerging Diseases·Manuel Saavedra-MontañezJosé Ivan Sánchez-Betancourt
Mar 20, 2020·PLoS Pathogens·Nídia S Trovão, Martha I Nelson
Feb 10, 2017·Transboundary and Emerging Diseases·J I Sánchez-BetancourtR A Segura-Velázquez
Feb 7, 2019·Frontiers in Veterinary Science·Daniela S RajaoDaniel R Perez
Mar 13, 2020·Scientific Reports·Rodrigo TapiaVíctor Neira
Nov 17, 2020·Frontiers in Veterinary Science·José Carlos Mancera GraciaMonica Balasch
Jan 29, 2020·Cold Spring Harbor Perspectives in Medicine·Tavis K AndersonAmy L Vincent

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BETA
PCR

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BEAST
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