Novel human neutrophil agonistic properties of arsenic trioxide: involvement of p38 mitogen-activated protein kinase and/or c-jun NH2-terminal MAPK but not extracellular signal-regulated kinases-1/2

Journal of Leukocyte Biology
François Binet, Denis Girard

Abstract

Arsenic trioxide (ATO) is known for treating acute promyelocytic leukemia and for inducing apoptosis and mitogen-activated protein kinases (MAPKs) in promyelocytes and cancer cells. We recently reported that ATO induces neutrophil apoptosis. The aim of this study was to establish whether or not ATO recruits MAPKs in neutrophils, as well as to further investigate its agonistic properties. We found that ATO activates p38 and that, unlike H2O2, this response was not inhibited by exogenous catalase. Also, we demonstrated that ATO-induced p38 activation occurs before H2O2 generation and without a calcium burst. We next established that ATO recruits c-jun NH2-terminal (JNK) but not extracellular signal-regulated kinase 1 and 2 (Erk-1/2). Using pharmacological inhibitors, we found that the proapoptotic activity of ATO occurs by a MAPK-independent mechanism. In contrast, the ability of ATO to enhance adhesion, migration, phagocytosis, release, and activity of gelatinase and degranulation of secretory, specific, and gelatinase, but not azurophilic granules, is dependent upon activation of p38 and/or JNK. This is the first study establishing that ATO possesses important agonistic properties in human neutrophils. Given the central role of...Continue Reading

References

Sep 23, 1998·Clinical Immunology and Immunopathology·D GirardA D Beaulieu
Sep 28, 1999·Molecular Medicine Today·E Herlaar, Z Brown
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J B KleinK R McLeish
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A MócsaiE Ligeti
Jun 1, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·V Witko-SarsatL Halbwachs-Mecarelli
Jan 6, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M GauthierD Girard
Feb 28, 2002·Annual Review of Immunology·Chen DongRichard A Flavell
Jun 22, 2002·Toxicology Letters·Michael F Hughes
Sep 20, 2002·The Journal of Biological Chemistry·Amit VermaLeonidas C Platanias
Dec 17, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Claude RatthéDenis Girard
Feb 1, 1963·Blood·J GHITIS
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Wen-Chien ChouChi V Dang
Mar 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Nopparat NuntharatanapongJohn F Keaney
Jan 5, 2007·American Journal of Physiology. Cell Physiology·Neelakshi R JogKenneth R McLeish
May 15, 2007·Oncogene·M RamanM H Cobb
Aug 8, 2007·Clinical and Experimental Immunology·E MoisanD Girard
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Veronica C ArdiJames P Quigley
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anthony LemarieLaurent Vernhet

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Citations

Mar 16, 2013·Annals of Hematology·Athena KritharisDaniel R Budman
Jan 13, 2015·Toxicology and Applied Pharmacology·Y S LeeH S Jun
Feb 9, 2010·International Immunopharmacology·François BinetDenis Girard
Dec 17, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D M GonçalvesD Girard
Nov 21, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Francis AntoineDenis Girard
Apr 8, 2009·Journal of Cellular Biochemistry·Emilie BourdonnayLaurent Vernhet
Nov 3, 2009·Biochemical and Biophysical Research Communications·François BinetDenis Girard
Jul 16, 2016·Journal of Immunotoxicology·Masumeh TaheriMohamad Hosein Mahmudy Gharaie
Jul 14, 2007·Vitamins and Hormones·Marco Tomasetti, Jiri Neuzil
May 27, 2010·Human & Experimental Toxicology·François BinetDenis Girard
Jul 19, 2019·Journal of Applied Toxicology : JAT·Su MingxingQiang Wang
Feb 6, 2020·British Journal of Pharmacology·Yishan YeFlorent Malard
Sep 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jamila Ennaciri, Denis Girard
Jan 28, 2010·Journal of Leukocyte Biology·Jean-Christophe SimardPhilippe A Tessier
Apr 10, 2018·Inflammation·Juan ZhangZhiyi Zhang

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