Novel in vivo techniques to visualize kidney anatomy and function

Kidney International
János Peti-PeterdiAnne Riquier-Brison

Abstract

Intravital imaging using multiphoton microscopy (MPM) has become an increasingly popular and widely used experimental technique in kidney research over the past few years. MPM allows deep optical sectioning of the intact, living kidney tissue with submicron resolution, which is unparalleled among intravital imaging approaches. MPM has solved a long-standing critical technical barrier in renal research to study several complex and inaccessible cell types and anatomical structures in vivo in their native environment. Comprehensive and quantitative kidney structure and function MPM studies helped our better understanding of the cellular and molecular mechanisms of the healthy and diseased kidney. This review summarizes recent in vivo MPM studies with a focus on the glomerulus and the filtration barrier, although select, glomerulus-related renal vascular and tubular functions are also mentioned. The latest applications of serial MPM of the same glomerulus in vivo, in the intact kidney over several days, during the progression of glomerular disease are discussed. This visual approach, in combination with genetically encoded fluorescent markers of cell lineage, has helped track the fate and function (e.g., cell calcium changes) of si...Continue Reading

References

Nov 1, 1995·Anatomy and Embryology·P Mundel, W Kriz
Jun 13, 2002·American Journal of Physiology. Renal Physiology·János Peti-PeterdiYasunobu Okada
Aug 15, 2002·American Journal of Physiology. Cell Physiology·Kenneth W DunnBruce A Molitoris
Apr 23, 2004·American Journal of Physiology. Cell Physiology·Ruben M SandovalBruce A Molitoris
Sep 16, 2004·American Journal of Physiology. Renal Physiology·H A PraetoriusJ Leipziger
Jan 29, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Donald J MarshNiels-Henrik Holstein-Rathlou
May 11, 2005·American Journal of Physiology. Renal Physiology·János Peti-Peterdi
May 11, 2005·American Journal of Physiology. Renal Physiology·Bruce A Molitoris, Ruben M Sandoval
Nov 22, 2005·Nature Methods·Fritjof Helmchen, Winfried Denk
Feb 24, 2006·American Journal of Physiology. Renal Physiology·János Peti-Peterdi
Mar 18, 2006·Nephron. Experimental Nephrology·Kenneth W Dunn, Pamela A Young
Mar 18, 2006·Nephron. Physiology·Ildikó TomaJános Peti-Peterdi
Apr 13, 2006·American Journal of Physiology. Renal Physiology·Jung Julie KangJanos Peti-Peterdi
Jul 27, 2006·American Journal of Physiology. Renal Physiology·László RosivallJános Peti-Peterdi
Feb 22, 2007·American Journal of Physiology. Renal Physiology·Weiming YuBruce A Molitoris
Aug 2, 2007·Kidney International·A SiposJ Peti-Peterdi
Sep 7, 2007·American Journal of Physiology. Renal Physiology·Andrew H J SalmonJános Peti-Peterdi
Oct 16, 2007·BioTechniques·Claudette St CroixSimon C Watkins
Jun 7, 2008·The Journal of Clinical Investigation·Ildikó TomaJános Peti-Peterdi
Jan 9, 2009·PLoS Biology·Aleksandr VasilyevIain A Drummond
Feb 13, 2009·American Journal of Physiology. Renal Physiology·George A Tanner
Apr 15, 2009·Physiology·János Peti-PeterdiSarah L Vargas
Nov 20, 2009·Kidney International·Peter Mundel, Jochen Reiser
Jun 26, 2010·Journal of the American Society of Nephrology : JASN·János Peti-Peterdi, Arnold Sipos
Oct 16, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lindsay Keir, Richard J M Coward
Mar 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Stefan WitteMarie Louise Groot
Jul 2, 2011·Journal of the American Society of Nephrology : JASN·Andrew M HallClaire M Peppiatt-Wildman
Oct 28, 2011·American Journal of Physiology. Renal Physiology·János Peti-PeterdiMatthias J Hackl
Jan 10, 2012·Journal of the American Society of Nephrology : JASN·Ruben M SandovalBruce A Molitoris
Mar 1, 2012·Journal of the American Society of Nephrology : JASN·Ivica GrgicBenjamin D Humphreys
Mar 24, 2012·Journal of the American Society of Nephrology : JASN·Weibin Zhou, Friedhelm Hildebrandt
Jul 17, 2012·Journal of the American Society of Nephrology : JASN·Andrew H J SalmonJanos Peti-Peterdi
Sep 21, 2012·Kidney International·Andrew M HallBruce A Molitoris
Sep 22, 2012·Journal of the American Society of Nephrology : JASN·Daisuke NakanoJanos Peti-Peterdi
Oct 2, 2012·Biochemical and Biophysical Research Communications·Charbel C KhourySheldon Chen
Nov 14, 2012·Nephron. Experimental Nephrology·C M Peppiatt-WildmanA M Hall
Dec 18, 2012·Nature Medicine·Sapna DeviMichael J Hickey
Dec 19, 2012·The American Journal of Pathology·Martin HöhneThomas Benzing
Mar 8, 2013·American Journal of Physiology. Renal Physiology·Peter R CorridonSimon J Atkinson
Oct 19, 2013·Frontiers in Physiology·Per SvenningsenJános Peti-Peterdi
Nov 16, 2013·The Journal of Clinical Investigation·Thomas SchaldeckerAnna Greka

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Citations

Oct 29, 2015·Kidney International·C D SchuhAndrew M Hall
Mar 13, 2016·Néphrologie & thérapeutique·János Peti-Peterdi
May 12, 2016·Kidney International·Michio Nagata
Mar 24, 2016·Current Opinion in Nephrology and Hypertension·János Peti-PeterdiAnne Riquier-Brison
Mar 30, 2016·Current Opinion in Nephrology and Hypertension·David A Ferenbach, Joseph V Bonventre
May 12, 2016·Kidney International·Nick Pullen, Alessia Fornoni
Aug 31, 2016·Nature Reviews. Nephrology·Luca PericoGiuseppe Remuzzi
Oct 16, 2016·Kidney International·János Peti-Peterdi
Feb 16, 2017·Transplantation·Michaela FinsterbuschMichael J Hickey
Feb 16, 2017·Current Opinion in Nephrology and Hypertension·Andrew M HallDominik Haenni
Jul 22, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maria Lucia AngelottiPaola Romagnani
Jun 23, 2020·American Journal of Physiology. Renal Physiology·Joana MartinsAndrew M Hall
Jul 1, 2017·Pflügers Archiv : European journal of physiology·James L BurfordJános Peti-Peterdi
Mar 21, 2017·International Journal of Biomedical Imaging·Hamid Tayebi KhosroshahiAbolhassan Shakeri Bavil
Feb 6, 2020·Current Medical Imaging Reviews·Aylin AkbulutMeliha Korkmaz
Sep 20, 2020·Nature Reviews. Nephrology·Suman RanjitMoshe Levi
Apr 10, 2019·Polymers·Marina VoinovaLeonid Gorelik
Oct 14, 2020·Journal of the American Society of Nephrology : JASN·Shinya YamamotoMotoko Yanagita
Jan 26, 2021·American Journal of Physiology. Renal Physiology·Georgina GyarmatiJános Peti-Peterdi
Jan 3, 2018·Seminars in Nephrology·Georgina GyarmatiJános Peti-Peterdi
Aug 3, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Weiwei LiuJiandong Gao
Oct 26, 2021·American Journal of Physiology. Renal Physiology·Urvi Nikhil ShroffJános Peti-Peterdi

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Methods Mentioned

BETA
electron microscopy
fluorescence imaging
fluorescence microscopy
light scattering
transgenic
transgenics
imaging techniques

Software Mentioned

MPM

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