Novel indolizine derivatives lowers blood glucose levels in streptozotocin-induced diabetic rats: A histopathological approach

Pharmacological Reports : PR
Vinay Bharadwaj TatipamulaRajendra Prasad Yejella

Abstract

Diabetes mellitus is a deadly disorder in human which induce chronic complications. The streptozotocin (STZ)-induced diabetes in rat is the most common animal model of human diabetes. The present study investigated the effects of novel indolizine derivatives (1-16) on plasma blood glucose concentrations in STZ-diabetic rats. In vitro experiments were performed on 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide free radicals, α-glucosidase enzyme and in vivo studies on normal, oral glucose loaded and STZ-induced diabetic rats. Among all synthetic derivatives, compound 12 showed good inhibitory profile against DPPH, superoxide free radicals and α-glucosidase enzyme with half maximal inhibitory concentration (IC50) values of 56.2, 33.5 and 26.5 μg/mL, respectively. The lethal dosage of indolizine derivatives was found to be above 1000 mg/kg body weight (b.w.). From the in vivo studies, it can be determined that the compound 12 depicted pronounced protective hypoglycemic effects in normal, glucose-loaded and STZ-induced diabetic rats with respect to the standard. Furthermore, 21 days of successive treatment with compound 12 in diabetic rats exhibited better recovery of body weight and considerable variations in biochemical paramet...Continue Reading

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Citations

Aug 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Israt JahanJesus Simal-Gandara
Sep 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ekaterina A SokolovaErik V Van der Eycken
Nov 16, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Guanting LiHongliang Huang
Dec 1, 2021·Cell Biochemistry and Function·Pınar Koroglu AydınRefiye Yanardag

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