Novel influenza vaccine M2SR protects against drifted H1N1 and H3N2 influenza virus challenge in ferrets with pre-existing immunity

Vaccine
Yasuko HattaPamuk Bilsel

Abstract

Current influenza vaccines do not provide effective protection against heterologous influenza viruses. The ability of the novel M2SR influenza vaccine to protect against drifted influenza viruses was evaluated in naïve ferrets and in ferrets with pre-existing immunity to influenza. In naïve ferrets, M2SR provided similar protection against drifted challenge viruses as the comparator vaccine, FluMist®. However, in ferrets with pre-existing immunity, M2SR provided superior protection than FluMist in two model systems. In the first model, ferrets were infected with influenza A H1N1pdm and influenza B viruses to mimic the diverse influenza exposure in humans. The pre-infected ferrets, seropositive to H1N1pdm and influenza B but seronegative to H3N2, were then vaccinated with H3N2 M2SR or monovalent H3N2 FluMist virus (A/Brisbane/10/2007, clade 1) and challenged 6 weeks later with a drifted H3N2 virus (clade 3C.2a). Antibody titers to Brisbane/10/2007 were higher in M2SR vaccinated ferrets than in FluMist vaccinated ferrets in the pre-infected ferrets whereas the opposite was observed in naïve ferrets. After challenge with drifted H3N2 virus, M2SR provided superior protection than FluMist monovalent vaccine. In the second model, the...Continue Reading

Citations

Oct 21, 2019·Journal of Biomedical Science·Daria MezhenskayaLarisa Rudenko
Mar 20, 2020·Journal of the Pediatric Infectious Diseases Society·John Treanor
Apr 12, 2020·Vaccines·Amanda L Skarlupka, Ted M Ross
Feb 16, 2020·Journal of Biomedical Science·Juine-Ruey ChenChe Ma
Oct 28, 2019·Frontiers in Cellular and Infection Microbiology·Yo Han Jang, Baik Lin Seong
Aug 15, 2020·Frontiers in Immunology·Lea Skak Filtenborg FrederiksenAneesh Thakur
Dec 5, 2018·Developmental and Comparative Immunology·Elisa Casadei, Irene Salinas
Apr 30, 2021·Biotechnology and Bioengineering·Sofia B CarvalhoRicardo J S Silva
Jun 3, 2021·Viruses·Thi-Quyen NguyenYoung-Ki Choi

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