Novel inhibitors of Leishmanial dihydrofolate reductase

Bioorganic & Medicinal Chemistry Letters
S F ChowdhuryI H Gilbert

Abstract

The program DOCK3.5 was used to search the Cambridge Structural Database for novel inhibitors of Leishmanial dihydrofolate reductase. A number of compounds were obtained and screened against the enzyme and against the intact parasite Leishmania donovani and the related organisms Trypanosoma brucei and Trypanosoma cruzi. The compounds screened showed weak activity in both the enzyme assays and the in vitro assays.

References

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Citations

Oct 15, 2003·Bioorganic & Medicinal Chemistry·Didier PezIan H Gilbert
Feb 19, 2002·International Journal for Parasitology·Marc OuelletteGaétan Roy
Jun 27, 2002·Biochimica Et Biophysica Acta·Ian H Gilbert
Jul 18, 2012·Future Medicinal Chemistry·Moni Sharma, Prem M S Chauhan
Nov 17, 2006·Nature Chemical Biology·Adam R Renslo, James H McKerrow
Sep 12, 2002·Expert Opinion on Therapeutic Targets·Karl A Werbovetz
Dec 1, 2006·Advances in Parasitology·Michael P Barrett, Ian H Gilbert
Oct 16, 2004·Expert Review of Anti-infective Therapy·Christina Naula, Richard Burchmore
May 7, 2002·Memórias do Instituto Oswaldo Cruz·José Rodriques Coura, Solange L de Castro
Oct 27, 2004·European Journal of Medicinal Chemistry·Susmita PandeyV M L Srivastava
Aug 3, 2019·Future Medicinal Chemistry·Gustavo Machado das NevesVera L Eifler-Lima
Sep 28, 2018·Current Medicinal Chemistry·María ValenteDolores González-Pacanowska

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