Novel insights into ferroptosis: Implications for age-related diseases.

Theranostics
Ren-Peng ZhouWei Hu

Abstract

Rapid increase in aging populations is an urgent problem because older adults are more likely to suffer from disabilities and age-related diseases (ARDs), burdening healthcare systems and society in general. ARDs are characterized by the progressive deterioration of tissues and organs over time, eventually leading to tissue and organ failure. To date, there are no effective interventions to prevent the progression of ARDs. Hence, there is an urgent need for new treatment strategies. Ferroptosis, an iron-dependent cell death, is linked to normal development and homeostasis. Accumulating evidence, however, has highlighted crucial roles for ferroptosis in ARDs, including neurodegenerative and cardiovascular diseases. In this review, we a) summarize initiation, regulatory mechanisms, and molecular signaling pathways involved in ferroptosis, b) discuss the direct and indirect involvement of the activation and/or inhibition of ferroptosis in the pathogenesis of some important diseases, and c) highlight therapeutic targets relevant for ARDs.

Citations

Apr 4, 2021·Biology·Ji-Yoon LeeEun-Woo Lee
Jul 15, 2021·Oxidative Medicine and Cellular Longevity·Yue ZhouJinwen Ge

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Methods Mentioned

BETA
GTPases
gene knockout
nuclear translocation
transgenic
MDA
bronchoalveolar lavage

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