Novel insights into lipid antigen presentation

Trends in Immunology
G De Libero, L Mori

Abstract

T cells recognizing lipid antigens are present in large numbers in circulating blood. They exert multiple functions including immunoregulation, tumour surveillance and protection during infection. Here, we review the latest information on the mechanisms of lipid antigen presentation by CD1 molecules. Recent studies have provided insight into CD1 trafficking within the cell, lipid distribution and handling, CD1 maturation, lipid antigen processing and loading. The structural resolution of all human CD1 molecules has revealed unique features that correlate with function. Molecular mechanisms regulating CD1 expression and multiple evasion mechanisms evolved by viral and bacterial pathogens have been disclosed. With rapid progression, these studies have decoded lipid-specific immunity and have revealed the important immunological role of this type of antigen recognition.

References

Dec 1, 1995·The Journal of Experimental Medicine·R R BrutkiewiczA Bendelac
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·V RibonA R Saltiel
Aug 19, 2000·The Journal of Biological Chemistry·C AngenieuxH de La Salle
Feb 7, 2001·Science·T I PrigozyM Kronenberg
Feb 16, 2002·The EMBO Journal·V BrikenS A Porcelli
Sep 20, 2002·The Journal of Biological Chemistry·Suk-Jo Kang, Peter Cresswell
Oct 9, 2002·Nature Immunology·Karen HoneyAlbert Bendelac
Oct 18, 2002·European Journal of Immunology·Sabrina MariottiRoberto Nisini
Jul 23, 2003·Nature Medicine·Ulrich E SchaibleStefan H E Kaufmann
Aug 12, 2003·Trends in Immunology·Christopher C Dascher, Michael B Brenner
Jan 13, 2004·Nature Immunology·Florian WinauUlrich E Schaible
Apr 27, 2004·Nature Medicine·Suzana BrozovicRichard S Blumberg
Mar 9, 2005·Traffic·Catherine AngénieuxHenri de la Salle
Oct 7, 2005·Nature·Peter van den ElzenMichael B Brenner
Nov 29, 2005·Science·Henri de la SalleGennaro De Libero
Apr 7, 2006·European Journal of Immunology·Vania ManolovaGennaro De Libero
Sep 20, 2006·The Journal of Experimental Medicine·Stephan D GadolaVincenzo Cerundolo
May 10, 2007·Nature Reviews. Microbiology·Emmanuel TupinMitchell Kronenberg
May 12, 2007·European Journal of Immunology·Jens SchümannGennaro De Libero
Nov 27, 2007·Nature Reviews. Immunology·Duarte C Barral, Michael B Brenner
Jan 23, 2008·Traffic·Blandine MaîtreHenri de la Salle
Feb 22, 2008·Journal of Virology·Martin J RafteryGünther Schönrich
May 1, 2008·Immunology·David S LeslieMichael B Brenner
Jun 10, 2008·Immunity·Miguel RellosoD Branch Moody
Jun 20, 2008·Traffic·Duarte C BarralMichael B Brenner
May 6, 2009·PloS One·Daryl CoxWilliam Hildebrand
May 27, 2009·The Journal of Experimental Medicine·Ildiko Van RhijnD Branch Moody
Jun 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Li BaiAlbert Bendelac

❮ Previous
Next ❯

Citations

Apr 26, 2013·The Journal of Biological Chemistry·Amit KuntePeter Cresswell
Oct 12, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Wenji SunTonya J Webb
Feb 7, 2014·Annual Review of Immunology·Mariolina SalioVincenzo Cerundolo
Oct 7, 2014·Trends in Immunology·Adrienne M LuomaErin J Adams
Oct 11, 2012·Immunological Reviews·Enrico Girardi, Dirk M Zajonc
Mar 11, 2015·British Journal of Pharmacology·Maria Ignez Gaspar-ElsasPedro Xavier-Elsas
Jun 5, 2015·International Journal of Immunogenetics·A AureliD Piancatelli
Aug 19, 2015·Immunological Reviews·Caitlin D CastroErin J Adams
Mar 24, 2015·Quarterly Reviews of Biophysics·Lucy MalininaRhoderick E Brown
Jun 7, 2014·Frontiers in Immunology·Gennaro De Libero, Lucia Mori
May 10, 2016·Human Immunology·Anna AureliDaniela Piancatelli
Mar 2, 2016·Annual Review of Immunology·Lucia MoriGennaro De Libero
Aug 4, 2016·The Journal of Allergy and Clinical Immunology·Daniela CernyKatja Fink
Jan 1, 2013·Annual Review of Animal Biosciences·Jeff HoldernessMark A Jutila
Sep 14, 2016·Trends in Immunology·Luc Van KaerSebastian Joyce
Mar 2, 2017·International Journal of Molecular Sciences·Cátia S PereiraM Fatima Macedo
Jan 11, 2017·Journal of Immunology Research·Catia S Pereira, M Fatima Macedo
May 17, 2013·The Journal of Biological Chemistry·Diana GarzónJosé D Faraldo-Gómez
Oct 17, 2018·Nature Communications·Shilpi ChandraMitchell Kronenberg
Jun 20, 2019·Frontiers in Immunology·Catia S PereiraM Fatima Macedo
Nov 14, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xingfang SuMadhavan Nallani
Jan 10, 2017·Frontiers in Immunology·Shouxiong Huang
Apr 13, 2018·Frontiers in Immunology·Christina MehrfeldVeronika Lukacs-Kornek
Jul 3, 2018·Frontiers in Immunology·Marco LeporeGennaro De Libero

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthrax Vaccines

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.

Anthrax

Anthrax toxin, comprising protective antigen, lethal factor, and oedema factor, is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in humans and animals. Here is the latest research on Anthrax.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Anthrax Vaccines (ASM)

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

Immunologic Research
L Mori, G De Libero
Current Opinion in Immunology
Mariolina SalioVincenzo Cerundolo
Current Opinion in Immunology
G De Libero, L Mori
Proceedings of the National Academy of Sciences of the United States of America
Luis F Garcia-AllesHenri de la Salle
© 2022 Meta ULC. All rights reserved