Novel insights into pretransplant allosensitization in heart transplant recipients in the contemporary era of immunosuppression and rejection surveillance

Transplant International : Official Journal of the European Society for Organ Transplantation
Eva SvobodovaIvan Malek

Abstract

Solid-phase assays (SPA) have facilitated detection and definition of antibodies to human leukocyte antigens (HLA) and major histocompatibility complex class I chain-related antigen A (MICA). However, clinical consequences of pretransplant SPA results in heart transplantation have been studied insufficiently in the current era of immunosuppression and rejection surveillance. Pretransplant sera, panel-reactive antibodies (PRA), pretransplant crossmatch, and clinical data were retrospectively analyzed in 264 adult heart transplant recipients. The specificity of HLA and MICA antibodies and C1q-binding activity of donor-specific antibodies (DSA) were defined using SPA. Pretransplant HLA antibodies were detected in 57 (22%) individuals, in 28 individuals (11%); these antibodies were DSA after transplant. Preformed DSA and elevated peak PRA were independent predictors of pathologic AMR, which occurred in 19 individuals (7%). The increasing number of DSA and the cumulative mean fluorescence intensity of DSA were associated with AMR. C1q-binding assay was a suboptimal predictor of AMR in our cohort. Pretransplant allosensitization and MICA antibodies were related neither to impaired graft survival nor to other adverse clinical events d...Continue Reading

References

Apr 3, 1969·The New England Journal of Medicine·R Patel, P I Terasaki
Nov 22, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Susan StewartMargaret E Billingham
Oct 3, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J D SmithM L Rose
Apr 1, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Teresa KaukeMichael Spannagl
Jul 1, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J D SmithM L Rose
Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Josef StehlikDavid D Eckels
Oct 19, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Clifford ChinDolly Tyan
Feb 9, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jon KobashigawaUNKNOWN Consensus Conference Participants
May 11, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Gerald J BerryMandeep R Mehra
Nov 13, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Adriana ZeeviSteven Webber
Mar 19, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Renee FrankPriti Lal
Aug 21, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Michelle RaessFrank Enseleit
Jun 25, 2015·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Tomas GazdicJosef Kautzner

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Citations

Mar 17, 2017·Current Opinion in Organ Transplantation·Valentina ManfrediniLuciano Potena
Aug 17, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Paloma TalayeroEsther Mancebo
Feb 20, 2019·Circulation·Monica M ColvinUNKNOWN American Heart Association Heart Failure and Transplantation Committee of the Council on Clinical Cardiology; Council on Car
Apr 3, 2019·Current Opinion in Organ Transplantation·Michael Olymbios, Jon A Kobashigawa
Apr 23, 2019·Current Opinion in Organ Transplantation·Markus J Barten, Andreas Zuckermann
Jul 21, 2017·Current Opinion in Organ Transplantation·Dolly B Tyan
Feb 14, 2017·Frontiers in Immunology·Massimo MangiolaAdriana Zeevi
May 16, 2019·Current Opinion in Organ Transplantation·Michael Olymbios, Jon A Kobashigawa
May 16, 2019·Current Opinion in Organ Transplantation·Shinichi Nunoda
May 16, 2019·Current Opinion in Organ Transplantation·Markus J Barten, Andreas Zuckermann
Dec 1, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jignesh K PatelJon A Kobashigawa

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