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Novel insights into RNAi off-target effects using C. elegans paralogs

BMC Genomics

Apr 19, 2007

Jean-François Rual, Niels Klitgord

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Abstract

In the few years since its discovery, RNAi has turned into a very powerful tool for the study of gene function by allowing post-transcriptional gene silencing. The RNAi mechanism, which is based on the introduction of a double-stranded RNA (dsRNA) trigger whose sequence is similar to th...read more

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  • Novel insights into RNAi off-target effects using C. elegans paralogs

    BMC Genomics

    Apr 19, 2007

    Jean-François Rual, Niels Klitgord

    PMID: 17445269

    DOI: 10.1186/1471-2164-8-106

    Abstract

    In the few years since its discovery, RNAi has turned into a very powerful tool for the study of gene function by allowing post-transcriptional gene silencing. The RNAi mechanism, which is based on the introduction of a double-stranded RNA (dsRNA) trigger whose sequence is similar to th...read more

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    • References31
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