Novel insights into the development of portal vein thrombosis in cirrhosis patients

Expert Review of Gastroenterology & Hepatology
Xingshun QiXiaozhong Guo

Abstract

The prognostic impact of portal vein thrombosis (PVT) in liver cirrhosis remains controversial among studies, primarily because the risk stratification of PVT is often lacking. A definition of clinically significant PVT should be proposed and actively improved. Moreover, the risk factors for the development of PVT in liver cirrhosis should be fully recognized to screen and identify high-risk patients. Currently, well-recognized risk factors include a reduced portal vein flow velocity, a worse liver function, splenectomy, liver transplantation, and factor V Leiden and prothrombin G20210A mutations. Novel risk factors include an increased flow volume of portosystemic collateral vessel, thrombopoietin receptor agnonists, and non-selective beta-blockers. In contrast to the traditional perspectives, the abnormalities of procoagulant and anticoagulant factors may not contribute to the development of PVT in liver cirrhosis. Further studies should explore the role of other risk factors, such as antiphospholipid antibodies, methylenetetrahydrofolate reductase C677T gene mutation, hyperhomocysteinemia, and myeloproliferative neoplasms.

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Citations

Aug 9, 2019·Expert Review of Gastroenterology & Hepatology·Marta Hernández-CondeJosé Luis Calleja
Feb 8, 2020·Clinical and Translational Gastroenterology·Michael PraktiknjoFrancesco Violi
Mar 10, 2016·European Journal of Gastroenterology & Hepatology·Kerstin RosenqvistRickard Nyman
Aug 24, 2017·Medicine·Mengjie LinYuzheng Zhuge
Jun 7, 2018·BMC Medicine·Xingshun QiDominique-Charles Valla
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Jul 20, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xingshun QiXiaozhong Guo
Dec 12, 2018·Transplantation Direct·Thomas A VerbeekDmitri Bezinover
Jun 6, 2020·European Journal of Gastroenterology & Hepatology·Le WangXingshun Qi

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