Novel insights into the effect of vitamin B₁₂ and omega-3 fatty acids on brain function

Journal of Biomedical Science
Richa S RathodSadhana R Joshi

Abstract

The prevalence of psychiatric disorders which are characterized by cognitive decline is increasing at an alarming rate and account for a significant proportion of the global disease burden. Evidences from human and animal studies indicate that neurocognitive development is influenced by various environmental factors including nutrition. It has been established that nutrition affects the brain throughout life. However, the mechanisms through which nutrition modulates mental health are still not well understood. It has been suggested that the deficiencies of both vitamin B12 and omega-3 fatty acids can have adverse effects on cognition and synaptic plasticity. Studies indicate a need for supplementation of vitamin B12 and omega-3 fatty acids to reduce the risk of cognitive decline, although the results of intervention trials using these nutrients in isolation are inconclusive. In the present article, we provide an overview of vitamin B12 and omega-3 fatty acids, the possible mechanisms and the evidences through which vitamin B12 and omega-3 fatty acids modulate mental health and cognition. Understanding the role of vitamin B12 and omega-3 fatty acids on brain functioning may provide important clues to prevent early cognitive defi...Continue Reading

References

May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·S A LiptonJ S Stamler
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·L CalzaR Levi-Montalcini
Dec 19, 2001·The Journal of Biological Chemistry·Donald B Jump
May 11, 2002·The Proceedings of the Nutrition Society·Patricia E Wainwright
Nov 29, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Joseph F Costello
Feb 20, 2003·Trends in Neurosciences·Mark P Mattson, Thomas B Shea
Nov 5, 2003·The Journal of Pediatrics·Sheila M Innis
Dec 6, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe ScalabrinoElena Mutti
Feb 6, 2004·Stroke; a Journal of Cerebral Circulation·Frank M Faraci, Steven R Lentz
May 4, 2004·Nature Reviews. Cancer·Mary-Ann Bjornsti, Peter J Houghton
Aug 18, 2004·Journal of the American College of Nutrition·Paola BenattiMenotti Calvani
Dec 9, 2004·The American Journal of Clinical Nutrition·S Jill JamesJames A Neubrander
Aug 9, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Neetu TyagiSuresh C Tyagi
Oct 4, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Jürgen GeiselWolfgang Herrmann
Nov 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·David LominadzeSuresh C Tyagi
Nov 10, 2005·European Journal of Clinical Nutrition·J C UmhauD T George
Dec 20, 2005·Journal of Neural Transmission·C LaskeK Schott
Jul 25, 2006·Cancer Biology & Therapy·Twan van den BeuckenBradly G Wouters
Oct 21, 2006·Lancet Neurology·Edward Reynolds
May 8, 2007·Trends in Cardiovascular Medicine·Pouneh Kermani, Barbara Hempstead
Sep 4, 2007·Microvascular Research·Beatrice NicoDomenico Ribatti
Oct 25, 2007·European Journal of Clinical Nutrition·S MuthayyaA V Kurpad
Aug 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Aron M TroenIrwin H Rosenberg
Oct 3, 2008·The Journal of Nutritional Biochemistry·Li-he JiangZhi-rong Yang
Nov 22, 2008·The Journal of Nutrition·Hyoju ChungDavid S Siscovick
Jun 1, 2006·Nutrition Research Reviews·C Sugden
Feb 21, 2009·Food and Nutrition Bulletin·Vidya BhateChittaranjan Yajnik
Jul 2, 2009·Human Reproduction Update·I CetinS Calabrese
Aug 18, 2009·Journal of Neurochemistry·Dehua CaoHee-Yong Kim
Oct 23, 2009·Journal of Neurology·Paula ScalzoAntônio Lúcio Teixeira
Apr 9, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Joe Leigh SimpsonWolfgang Holzgreve

❮ Previous
Next ❯

Citations

Jan 6, 2018·Current Medicinal Chemistry·Leonardo F FontenelleMurat Yücel
Aug 17, 2018·Nutrients·Erin L RichardLinda K McEvoy
Jan 9, 2019·Frontiers in Psychology·Alexandra PantzarMaria M Ekblom
Mar 29, 2019·Food Science & Nutrition·Ji LiuShenglan Zhao
Feb 12, 2021·Journal of Applied Microbiology·Nivetha KannanA Nair

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Evidence Report/technology Assessment
H M SchachterM Miguelez
Prostaglandins, Leukotrienes, and Essential Fatty Acids
Amrita A KhaireSadhana R Joshi
Clinical Interventions in Aging
Gregory A Jicha, William R Markesbery
© 2021 Meta ULC. All rights reserved