Novel insights into the function and dynamics of extracellular matrix in liver fibrosis

American Journal of Physiology. Gastrointestinal and Liver Physiology
Morten Asser KarsdalDetlef Schuppan

Abstract

Emerging evidence suggests that altered components and posttranslational modifications of proteins in the extracellular matrix (ECM) may both initiate and drive disease progression. The ECM is a complex grid consisting of multiple proteins, most of which play a vital role in containing the essential information needed for maintenance of a sophisticated structure anchoring the cells and sustaining normal function of tissues. Therefore, the matrix itself may be considered as a paracrine/endocrine entity, with more complex functions than previously appreciated. The aims of this review are to 1) explore key structural and functional components of the ECM as exemplified by monogenetic disorders leading to severe pathologies, 2) discuss selected pathological posttranslational modifications of ECM proteins resulting in altered functional (signaling) properties from the original structural proteins, and 3) discuss how these findings support the novel concept that an increasing number of components of the ECM harbor signaling functions that can modulate fibrotic liver disease. The ECM entails functions in addition to anchoring cells and modulating their migratory behavior. Key ECM components and their posttranslational modifications oft...Continue Reading

References

Sep 1, 1977·The Journal of Experimental Medicine·D E TrenthamA H Kang
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·B Mintz, K Illmensee
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D J GoodN P Bouck
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·L Ala-KokkoD J Prockop
Jun 1, 1991·The Journal of Pathology·G Abdel-AzizA Guillouzo
Sep 1, 1990·American Journal of Medical Genetics·T E BesserG G Knowlen
Nov 1, 1990·The Journal of Clinical Investigation·S KontusaariD J Prockop
Apr 1, 1987·The Journal of Clinical Investigation·A S AschR L Nachman
Feb 1, 1986·Calcified Tissue International·D GonzálezC Mautalen
Jan 1, 1986·Journal of Hepatology·J H Lefkowitch, L Mendez
Aug 1, 1981·The Biochemical Journal·M Paulsson, D Heinegård
Oct 1, 1994·Gut·A M Gressner
Jan 1, 1995·Annual Review of Cell and Developmental Biology·M A SchwartzM H Ginsberg
Jan 1, 1996·Annual Review of Nutrition·K Jungermann, T Kietzmann
Nov 1, 1996·Experimental Cell Research·J C AtkinsonD Schuppan
Nov 29, 1996·Clinica Chimica Acta; International Journal of Clinical Chemistry·O OdaN Yamanaka
Jan 1, 1996·Annual Review of Cell and Developmental Biology·E Ruoslahti
Feb 10, 1997·The Journal of Cell Biology·K G DanielsonR V Iozzo
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·X LiuR Jaenisch
Jan 15, 1998·Gastroenterology·D SchuppanE O Riecken
Apr 16, 1998·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·M Aumailley, B Gayraud
Jul 24, 1998·Archives of Biochemistry and Biophysics·R J FernandesD R Eyre
Aug 12, 1998·American Journal of Respiratory and Critical Care Medicine·E C LuceyG L Snider
Sep 22, 1998·Lancet·D SchuppanH Herbst
Oct 23, 1998·Journal of Medical Genetics·A J RichardsN P Burrows
Oct 31, 1998·Journal of Viral Hepatitis·R IdilmanD H Van Thiel
Feb 24, 1999·Nature·C D BuckleyM Salmon
Mar 2, 1999·Biochemical and Biophysical Research Communications·R RamchandranV P Sukhatme

❮ Previous
Next ❯

Citations

Jan 19, 2016·Frontiers in Pharmacology·Ralf Weiskirchen
Dec 24, 2015·Frontiers in Physiology·Jan GörtzenJonel Trebicka
Aug 27, 2015·Journal of Hepatology·Morten A KarsdalDetlef Schuppan
Nov 28, 2015·Journal of Physiology and Biochemistry·Ming-ming NiJun Li
Oct 17, 2015·Fibrogenesis & Tissue Repair·Katharine M IrvineElizabeth E Powell
Jul 21, 2015·Clinics and Research in Hepatology and Gastroenterology·Detlef Schuppan
Apr 15, 2016·Journal of Clinical Medicine·Sonsoles Piera-VelazquezSergio A Jimenez
Jun 14, 2016·Canadian Journal of Physiology and Pharmacology·Ying-Hua HeJun Li
Sep 16, 2016·Diabetologia·Morten A KarsdalDetlef Schuppan
Jun 29, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hannah JonesHeather Francis
Feb 6, 2017·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Hossain M GolbarJyoji Yamate
Oct 19, 2017·International Journal of Molecular Sciences·Evangelia PardaliPeter Ten Dijke
Oct 22, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Morten A KarsdalDetlef Schuppan
Feb 7, 2018·BMC Complementary and Alternative Medicine·Cheng ChiCheng-Hong Yin
Dec 29, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dae-Geun SongJung Weon Lee
Mar 23, 2019·Assay and Drug Development Technologies·Lela Stefanovic, Branko Stefanovic
Jul 26, 2019·Alimentary Pharmacology & Therapeutics·Yvonne HuberJörn M Schattenberg
Jan 30, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Chadalavada Vijay KrishnaSatish Rattan
Dec 13, 2017·Scientific Reports·Daniel Guldager Kring RasmussenPaul Cockwell
Sep 26, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Morten A KarsdalDetlef Schuppan
Dec 19, 2019·Expert Review of Molecular Diagnostics·Anne Christine Bay-JensenMorten Asser Karsdal
Nov 28, 2019·Cells·Edith Hintermann, Urs Christen
Dec 10, 2019·Current Pharmaceutical Design·Mengyu LiLijian Tao
Jan 31, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Morten A KarsdalDetlef Schuppan
Nov 8, 2019·Annals of the New York Academy of Sciences·Zohreh KhajehahmadiHeidar Tavilani
Oct 28, 2019·Current Opinion in Pulmonary Medicine·Thomas BahmerMarkus Weckmann
Apr 4, 2020·Seminars in Liver Disease·Michitaka Matsuda, Ekihiro Seki
Mar 13, 2020·Seminars in Liver Disease·Luca FabrisGregory J Gores
Aug 30, 2017·Haemophilia : the Official Journal of the World Federation of Hemophilia·T Manon-JensenM A Karsdal
Jan 3, 2018·The Journal of Clinical Investigation·Joon-Il Jun, Lester F Lau
Aug 16, 2018·Dose-response : a Publication of International Hormesis Society·Cornel BaltaAnca Hermenean

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved