Novel insights on testicular volume and testosterone replacement therapy in Klinefelter patients undergoing testicular sperm extraction. A retrospective clinical study

Clinical Endocrinology
Andrea GarollaCarlo Foresta


To investigate whether sperm recovery is related to clinical features, hormone parameters and testosterone replacement therapy (TRT) in patients with Klinefelter syndrome (KS). This study provides three interesting insights: (i) the probability to retrieve sperm is not related to testicular volume; (ii) TRT does not affect sperm retrieval rate (SRR); and (iii) reduced levels of LH and FSH represent a negative predictor of sperm retrieval in patients with TRT. Classical KS shows a karyotype with one extra X chromosome in all of somatic cells and clinical manifestations characterized by hypergonadotropic hypogonadism and infertility. We performed a retrospective cohort study. Data from 111 consecutive KS azoospermic patients undergoing testicular sperm extraction (TESE) were collected from 2005 to 2016. Data on anthropometric parameters, reproductive hormones and testicular volumes were collected. SRR was related to clinical characteristics and compared between TRT and untreated patients. A total of 38 patients (34.2%) had successful sperm recovery. The comparison of clinical characteristics did not differ between patients with and without sperm recovery. Sperm retrieval was successful also in subjects with smaller testes. The co...Continue Reading


Mar 15, 1969·Nature·N E SkakkebaekR Hammen
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·E SteinbergerW H Perloff
Apr 1, 1995·International Journal of Andrology·J MüllerS G Ratcliffe
Dec 1, 1996·Human Reproduction·E Van AsscheI Liebaers
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·A VermeulenJ M Kaufman
Feb 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Anders BojesenClaus Højbjerg Gravholt
May 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Anne M WikströmLeo Dunkel
Jul 21, 2004·Lancet·Fabio LanfrancoEberhard Nieschlag
Oct 16, 2004·Fertility and Sterility·Dominik DenschlagChristoph Keck
Oct 6, 2005·The Journal of Clinical Endocrinology and Metabolism·Anthony J SwerdlowUNKNOWN United Kingdom Clinical Cytogenetics Group
Nov 11, 2006·Urology·Mustafa Emre BakirciogluMustafa Bahceci
May 6, 2008·Urology·Tomomoto IshikawaMasato Fujisawa
Oct 4, 2008·Current Opinion in Urology·Darius A PaduchJoseph Kiper
Jun 12, 2009·International Journal of Andrology·L AksglaedeA Juul
Jul 21, 2009·The Journal of Urology·Ranjith RamasamyPeter N Schlegel
Mar 25, 2010·Journal of Endocrinological Investigation·R SeliceC Foresta
Jul 29, 2010·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·G FortiM Maggi
Feb 8, 2011·Fertility and Sterility·Mustafa Emre BakirciogluMustafa Bahceci
Mar 15, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Anne M Wikström, Leo Dunkel
Mar 19, 2011·Acta Paediatrica·Anders Bojesen, Claus H Gravholt
Apr 1, 2011·The Medical Journal of Australia·Amy S HerlihyRobert I McLachlan
Jun 27, 2012·Fertility and Sterility·Akanksha Mehta, Darius A Paduch
Mar 19, 2013·European Journal of Endocrinology·L Aksglaede, A Juul
Nov 26, 2014·The Journal of Clinical Endocrinology and Metabolism·Ingrid PlottonUNKNOWN FERTIPRESERVE group
Apr 6, 2017·Human Reproduction Update·Giovanni CoronaUNKNOWN Klinefelter ItaliaN Group (KING)

❮ Previous
Next ❯


Oct 8, 2019·Expert Review of Endocrinology & Metabolism·Jonathan FainbergPeter N Schlegel
Jun 5, 2020·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Simon ChangClaus H Gravholt
Jun 23, 2020·Journal of Endocrinological Investigation·A PizzocaroUNKNOWN King, Klinefelter ItaliaN Group
Sep 3, 2020·Scientific Reports·Joachim WistubaJörg Gromoll

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.