Novel insights on testicular volume and testosterone replacement therapy in Klinefelter patients undergoing testicular sperm extraction. A retrospective clinical study

Clinical Endocrinology
Andrea GarollaCarlo Foresta

Abstract

To investigate whether sperm recovery is related to clinical features, hormone parameters and testosterone replacement therapy (TRT) in patients with Klinefelter syndrome (KS). This study provides three interesting insights: (i) the probability to retrieve sperm is not related to testicular volume; (ii) TRT does not affect sperm retrieval rate (SRR); and (iii) reduced levels of LH and FSH represent a negative predictor of sperm retrieval in patients with TRT. Classical KS shows a karyotype with one extra X chromosome in all of somatic cells and clinical manifestations characterized by hypergonadotropic hypogonadism and infertility. We performed a retrospective cohort study. Data from 111 consecutive KS azoospermic patients undergoing testicular sperm extraction (TESE) were collected from 2005 to 2016. Data on anthropometric parameters, reproductive hormones and testicular volumes were collected. SRR was related to clinical characteristics and compared between TRT and untreated patients. A total of 38 patients (34.2%) had successful sperm recovery. The comparison of clinical characteristics did not differ between patients with and without sperm recovery. Sperm retrieval was successful also in subjects with smaller testes. The co...Continue Reading

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Oct 8, 2019·Expert Review of Endocrinology & Metabolism·Jonathan FainbergPeter N Schlegel
Jun 5, 2020·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Simon ChangClaus H Gravholt
Jun 23, 2020·Journal of Endocrinological Investigation·A PizzocaroUNKNOWN King, Klinefelter ItaliaN Group
Sep 3, 2020·Scientific Reports·Joachim WistubaJörg Gromoll

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