Novel insights regarding anaphylaxis in children - With a focus on prevalence, diagnosis, and treatment.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Ken-Ichi NagakuraMotohiro Ebisawa

Abstract

Anaphylaxis is a serious allergic reaction that occurs rapidly and causes a life-threatening response involving the whole body. This reaction often leads to difficulty in breathing and can result in death. The estimated prevalence of anaphylaxis is 0.05%-2%, which is reported to be increasing in children. Although drugs and venom are the most common causes of anaphylaxis in adults, food is the most common cause of anaphylaxis in children. An interesting association between food-dependent exercise-induced anaphylaxis (FDEIA) and oral immunotherapy (OIT) has recently been reported. A provocation test to determine the diagnostic and augmenting factors of FDEIA has been reported in recent years. Remarkably, several articles showed allergic symptoms without exercise in children with FDEIA and in those with FDEIA development after OIT. Regarding OIT, full-dose OIT poses a risk of adverse reactions, including anaphylaxis. Recent trials have shown the efficacy and safety of low-dose OIT in patients with food-induced anaphylaxis. In this review, we summarized the novel insights regarding anaphylaxis in the pediatric population.

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Citations

Jan 20, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Philippe Eigenmann
Jan 23, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Philippe A EigenmannRobert A Wood
Mar 6, 2021·Current Allergy and Asthma Reports·Brittany BoswellJulie C Brown
Mar 29, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ângela GasparUNKNOWN Portuguese Society of Allergology and Clinical Immunology (SPAIC) Anaphylaxis Interest Group
Dec 27, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Ken-Ichi NagakuraMotohiro Ebisawa

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