Novel Intrapolymerization Doped Manganese-Eumelanin Coordination Nanocomposites with Ultrahigh Relaxivity and Their Application in Tumor Theranostics

Advanced Science
Heng LiuXiaoyuan Chen

Abstract

While magnetic resonance imaging contrast agents have potential in noninvasive image-guided tumor treatment, further developments are needed to increase contrast, biodegradability, and safety. Here, novel engineered manganese-eumelanin coordination nanocomposites (MnEMNPs) are developed via a facile one-pot intrapolymerization doping (IPD) approach in aqueous solution, through simple chemical oxidation-polymerization of the 3,4-dihydroxy-DL-phenylalanine precursor with potassium permanganate serving as the Mn source and an oxidant. The resulting MnEMNPs possess ultrahigh longitudinal relaxivity (r1 value up to 60.8 mM-1 s-1 at 1.5 T) attributed to the high manganese doping efficiency (>10%) and geometrically confined conformation. Due to their high manganese chelation stability, excellent biocompatibility, and strong near-infrared absorption, high-performance longitudinal-transverse (T1-T2) dual-modal magnetic resonance/photoacoustic imaging and photothermal tumor ablation are achieved. Furthermore, the hydrogen peroxide-triggered decomposition behavior of MnEMNPs circumvents the poor biodegradation issue of many nanomaterials. This facile, convenient, economical, and efficient IPD strategy will open up new avenues for the deve...Continue Reading

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Citations

Sep 12, 2019·Advanced Science·Ming-Kang ZhangXian-Zheng Zhang
Sep 20, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Haonan LiKui Luo
Sep 27, 2018·Advanced Materials·Zhenjie XueTie Wang
Feb 9, 2021·Global Challenges·Hanaa A GalebJohn G Hardy
Nov 21, 2020·Nanomaterials·Alexandra Mavridi-PrinteziMarco Montalti
Jan 7, 2021·International Journal of Molecular Sciences·Yale Yue, Xiao Zhao

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Methods Mentioned

BETA
transmission electron microscopy
electron spin resonance
X‐ray
ESR
nuclear magnetic relaxation
dynamic light scattering

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