Novel investigational therapies for onychomycosis: an update

Expert Opinion on Investigational Drugs
A K Gupta, Catherine Studholme

Abstract

Onychomycosis is an infection of the nail plate that is prevalent among the ageing population. Onychomycosis is difficult to treat with low initial cure rates, high rates of relapse, and reinfection. Present treatment options include oral and topical therapies, with oral therapies yielding better results. However, there has been a greater emphasis on the development of topical antifungal therapies as they have fewer side effects and drug interactions. This review summarizes new and reformulated drugs. Results from in vitro studies to Phase III clinical trials are discussed. Novel drugs include: the oral azole VT-1161, the topical azole efinaconazole, the benzoxaborole tavaborole, reformulations of terbinafine P-3058 and LI-P, novel inhibitor of succinate dehydrogenase ME1111, and off-label use of tazarotene. Enhanced permeation of the morpholine amorolfine through the nail plate is also discussed using ultraviolet (UV) curable gels, and a fractional CO2 laser. Novel topical antifungals and the reformulation of current antifungals have demonstrated marked improvement in nail penetration. Current research has an emphasis on topical therapies due to their minimized risk for adverse effects and higher patient demand. Nevertheless, ...Continue Reading

References

Jan 7, 1998·Journal of the American Academy of Dermatology·A K Gupta, N H Shear
Sep 10, 1998·Dermatology : International Journal for Clinical and Investigative Dermatology·A TostiM D Colombo
Jan 20, 1999·The British Journal of Dermatology·A K GuptaR C Summerbell
Jan 19, 2000·Current Pharmaceutical Design·S M ThacherR A Chandraratna
Nov 30, 2000·International Journal of Dermatology·A K GuptaR C Summerbell
Jul 11, 2001·Journal of the European Academy of Dermatology and Venereology : JEADV·A K GuptaK A Harris
Mar 14, 2002·International Journal of Pharmaceutics·Sudaxshina Murdan
Oct 23, 2003·Dermatology : International Journal for Clinical and Investigative Dermatology·Jorge E Arrese, Gérald E Piérard
Mar 5, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yoichi KobayashiYasunori Morimoto
Apr 23, 2004·The Journal of Investigative Dermatology·Augusto OrlandiSergio Chimenti
Aug 27, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·A TostiR Arenas-Guzmán
Aug 9, 2007·Expert Opinion on Drug Delivery·Sudaxshina Murdan
Nov 4, 2008·Expert Opinion on Drug Delivery·Sudaxshina Murdan
Mar 30, 2010·Clinics in Dermatology·Oliverio WelshEsperanza Welsh
Sep 21, 2010·Transplant Infectious Disease : an Official Journal of the Transplantation Society·N I BakrM A Bakr
Dec 15, 2010·Clinics in Dermatology·Robert Baran
Feb 1, 2011·Dermatologic Therapy·Emily P TierneyC William Hanke
Jun 4, 2011·Thérapie·Anne HulinUNKNOWN Groupe Suivi Therapeutique Pharmacologique de la Societe Francaise de Pharmacologie et de Therapeutique
Aug 9, 2011·Journal of the American Academy of Dermatology·Aditya K GuptaAntonella Tosti
Aug 10, 2012·Drug Development and Industrial Pharmacy·Xiaoying HuiHoward I Maibach
Sep 20, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Emily P Tierney, C William Hanke
Oct 2, 2013·Clinics in Dermatology·Aditya K GuptaFiona C Simpson
Mar 25, 2014·Journal of the American Academy of Dermatology·Eun-Hwa LimMyung Im
Jun 21, 2014·Bioorganic & Medicinal Chemistry Letters·William J HoekstraRobert J Schotzinger
Aug 15, 2014·Drugs·Anthony Markham
Dec 20, 2014·Expert Opinion on Pharmacotherapy·Aditya K Gupta, Fiona C Simpson
Mar 4, 2015·Drug Design, Development and Therapy·Elena CampioneAugusto Orlandi
Jul 19, 2015·International Journal of Pharmaceutics·Laxmi Valji KeraiSudaxshina Murdan
Mar 1, 2011·Thérapie·Anne HulinUNKNOWN pour le groupe Suivi Thérapeutique Pharmacologique de la Société Française de Pharmacologie et de Thérapeutique

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Citations

Nov 26, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Veronika OpletalovaMarta Kucerova-Chlupacova
May 13, 2017·Nature Reviews. Drug Discovery·John R Perfect
Jun 24, 2017·Journal of Cutaneous Medicine and Surgery·Aditya K GuptaNeil H Shear
May 17, 2019·Pharmaceutical Nanotechnology·Rupinder K DhamoonMadhu Gupta
Mar 10, 2018·Journal of the American Podiatric Medical Association·Aditya K Gupta, Sarah G Versteeg
Jul 13, 2018·Expert Review of Hematology·Douglas Tremblay, John Mascarenhas
Aug 10, 2016·Mycopathologia·Aditya K GuptaSarah G Versteeg
Oct 28, 2016·Mycopathologia·Daniel Asz-SigallRoberto Arenas

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