Novel Key Players in the Development of Tau Neuropathology: Focus on the 5-Lipoxygenase

Journal of Alzheimer's Disease : JAD
Elisabetta Lauretti, Domenico Praticò

Abstract

Tauopathies belong to a large group of neurodegenerative diseases characterized by progressive accumulation of hyperphosphorylated tau. Tau is a microtubule binding protein which is necessary for their assembly and stability. However, tau affinity for microtubules mainly depends on its phosphorylation status, which is the result of a delicate balance between kinases and phosphatases activity. Any significant changes in this equilibrium can promote tau fibrillation, aggregation, neuronal dysfunction, and ultimately neuronal loss. Despite intensive research, the molecular mechanism(s) leading to tau hyperphosphorylation are still unknown and there is no cure for these diseases. Development of an effective strategy that successfully prevents tau excessive phosphorylation and/or tau aggregation may offer a real therapeutic opportunity for these less investigated neurodegenerative conditions. Beside tau, chronic brain inflammation is a common feature of all tauopathies and 5-lipoxygenase, an inflammatory enzyme, is upregulated in brain regions affected by tau pathology. Recently, in vitro studies and preclinical investigations with animal models of tauopathy have implicated 5-lipoxygenase in the regulation of tau phosphorylation thr...Continue Reading

References

Jun 12, 2001·Journal of Neuropathology and Experimental Neurology·K Ishizawa, D W Dickson
Aug 31, 2001·Microscopy Research and Technique·P J Gebicke-Haerter
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Leila Tarsa, Yukiko Goda
Dec 4, 2003·Neurobiology of Aging·Salvatore OddoFrank M LaFerla
Feb 26, 2005·Stroke; a Journal of Cerebral Circulation·Elin LõhmussaarMartin Dichgans
Sep 30, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masashi KitazawaFrank M LaFerla
Aug 26, 2006·Neurobiology of Aging·Cinzia M ChinniciDomenico Praticò
Oct 25, 2008·The Journal of Biological Chemistry·Michael S Wolfe
Aug 28, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Manuela PolydoroPeter Davies
Nov 26, 2009·Cardiovascular Psychiatry and Neurology·Jin Chu, Domenico Praticò
Jan 27, 2010·The Mount Sinai Journal of Medicine, New York·Maria Jose Metcalfe, Maria E Figueiredo-Pereira
May 25, 2010·Biochemical and Biophysical Research Communications·Olof Rådmark, Bengt Samuelsson
Aug 4, 2010·Current Alzheimer Research·K IqbalI Grundke-Iqbal
Feb 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Astrid SydowEva-Maria Mandelkow
Jun 8, 2011·Molecular Neurodegeneration·Cristian A Lasagna-ReevesRakez Kayed
Aug 5, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrej KovacMichal Novak
Jul 27, 2012·The Journal of Biological Chemistry·Siddhartha Mondragón-RodríguezJannic Boehm
Nov 26, 2013·Biochemical Pharmacology·Phillip F GiannopoulosDomenico Praticò
Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christine E Taft, Gina G Turrigiano
Apr 9, 2014·World Journal of Urology·Timothy K Byler, Gennady Bratslavsky
Feb 3, 2015·Frontiers in Cellular Neuroscience·Yash B Joshi, Domenico Praticò
Jun 20, 2015·Frontiers in Neuroscience·Nicole MaphisKiran Bhaskar
Sep 19, 2015·Parkinsonism & Related Disorders·David J Irwin
Dec 4, 2015·Nature Reviews. Neuroscience·Yipeng Wang, Eckhard Mandelkow
May 14, 2016·Science Translational Medicine·Matthew R BrierBeau M Ances
Oct 26, 2016·Brain Research Bulletin·Thomas ArendtMax Holzer
Jan 27, 2017·Science Translational Medicine·Sarah L DeVosTimothy M Miller
Nov 13, 2017·Molecular Neurobiology·Phillip F Giannopoulos, Domenico Praticò

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Citations

Mar 3, 2020·Expert Opinion on Therapeutic Targets·Elisabetta Lauretti, Domenico Praticò
Mar 3, 2020·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Samuel J PoirierMarc E Surette

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