PMID: 8955510Nov 1, 1996Paper

Novel L-lyxo and 5'-deoxy-5'-modified TSAO-T analogs: synthesis and anti-HIV-1 activity

Antiviral Research
S IngateM J Camarasa

Abstract

Novel L-lyxo-TSAO-T analogs with an inverted configuration at the C-4'-position of the sugar moiety and 5'-deoxy-5'-modified TSAO-T derivatives have been prepared and evaluated for their inhibitory effect on human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) replication in cell culture. None of the compounds showed marked antiviral efficacy. The inactivity of the TSAO-T derivatives may most likely be explained by either their different 4'-configuration or their different chemical structure that may not allow an optimal interaction of the molecules with the lipophilic binding pocket of the HIV-1 reverse transcriptase.

References

Dec 1, 1989·Journal of Medicinal Chemistry·T MiyasakaE De Clercq
Dec 29, 1989·Biochemical and Biophysical Research Communications·M BabaT Miyasaka
Apr 1, 1995·Nature Structural Biology·J RenD Stuart

❮ Previous
Next ❯

Citations

Mar 27, 2004·Nucleosides, Nucleotides & Nucleic Acids·Erik De Clercq

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.