Novel Lactobacillus reuteri HI120 Affects Lipid Metabolism in C57BL/6 Obese Mice

Frontiers in Veterinary Science
Ye SunYang Bai

Abstract

Intestinal probiotics are a primary focus area of current medical research. Probiotics such as bifidobacteria and lactobacilli can positively impact obesity and other metabolic diseases by directly or indirectly affecting lipid metabolism. However, the precise mechanisms of these effects remain unclear. In our previous work, the novel strain Lactobacillus reuteri HI120 was isolated and identified. HI120 expresses high levels of linoleic isomerase, resulting in the production of large amounts of conjugated linoleic acid (CLA) when mixed with linoleic acid (LA). As HI120 can efficiently transform LA into CLA, the effect of HI120 on the lipid metabolism in C57BL/6 obese mice was studied and the underlying molecular mechanism was explored in vitro. The results revealed no significant change in the diet, body weight, and serum triglyceride levels in mice. However, serum cholesterol levels were significantly decreased. The underlying mechanism may involve a CLA-mediated reduction in the gene expression levels of NPC1L1, SREBP-2, and HMG-CR, resulting in reduced cholesterol synthesis and absorption. Thus, HI120 can be developed as a potential probiotic formulation. After oral administration, LA from certain food sources can be convert...Continue Reading

References

Feb 1, 1990·Nature·J L Goldstein, M S Brown
May 1, 1974·The American Journal of Clinical Nutrition·G V Mann
Sep 1, 1963·The American Journal of Clinical Nutrition·A G SHAPERJ KYOBE
Feb 21, 2004·Science·Scott W AltmannMichael P Graziano
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Alena LiavonchankaMarkus Georg Rudolph
Feb 24, 2006·Bioscience, Biotechnology, and Biochemistry·Yu-Ming WangTeruyoshi Yanagita
Sep 30, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Waddah A AlrefaiRavinder K Gill
Feb 3, 2009·Vascular Health and Risk Management·Anbu PandianBobby V Khan
Jan 30, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Tomoyuki YasudaDaniel J Rader
Apr 30, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pradeep KumarWaddah A Alrefai
Jul 20, 2012·Journal of Lipid Research·Chang Xie 谢畅Bao-Liang Song 宋保亮
Jun 5, 2013·Journal of Diabetes and Its Complications·A Gordon Smith, J Robinson Singleton
Jun 22, 2014·Current Cardiology Reports·Alan A HennessyCatherine Stanton
Jun 18, 2016·Journal of Lipid Research·Marleen SchonewilleAlbert K Groen
Jun 28, 2017·Chemistry : a European Journal·Stefan SchoderHans-Ulrich Reissig
Sep 5, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David E StecTerry D Hinds
Feb 25, 2020·Indian Journal of Microbiology·Nirjara SinghviRup Lal
Jun 25, 2020·Vaccines·Georgios Aindelis, Katerina Chlichlia
Jul 28, 2020·International Journal of Obesity Supplements·Paolo MarzulloUNKNOWN Obesity Programs of nutrition, Education, Research and Assessment (OPERA) Group

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BETA
PCR
transfection

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GraphPad Prism

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