PMID: 9531982Apr 9, 1998Paper

Novel lactone compounds from Mortierella verticillata that induce the human low density lipoprotein receptor gene: fermentation, isolation, structural elucidation and biological activities

The Journal of Antibiotics
K A DekkerN Kojima

Abstract

Among methods of controlling hypercholesterolemia and hyperlipidemia is the direct stimulation of hepatic low density lipoprotein (LDL) receptors. Two novel lactone compounds, CJ-12,950 and CJ-13,357, containing and unusual oxime moiety, were isolated from a zygomycete Mortierella verticillata. These lactones are potent inducers of the LDL receptor gene in vitro, that enhanced LDL receptor expression in human hepatocytes 2-fold at 100 nM.

Citations

Feb 2, 2002·Chemistry : a European Journal·A FürstnerG Blanda
Jun 1, 2016·ChemMedChem·Christopher M SchneiderGunda I Georg
Jan 2, 2009·Journal of Medicinal Chemistry·Yoshinori SugimotoTohru Oishi
Aug 31, 2002·Organic Letters·Ruichao ShenJohn A Porco
Nov 29, 2011·The Journal of Organic Chemistry·Sanjay S PalimkarHiromi Ii
Jan 8, 2013·The Journal of Organic Chemistry·Anand Kumar PandeyPrem M S Chauhan
Sep 19, 2017·Journal of Natural Products·Alyssa L GrunwaldRussell G Kerr
Sep 11, 2021·Proceedings of the National Academy of Sciences of the United States of America·Hannah BüttnerChristian Hertweck
Sep 26, 2003·Organic Letters·Lei JiangStephen L Buchwald

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