PMID: 7538482Jan 1, 1995Paper

Novel leukemic lymphoma with probable derivation from immature stage of natural killer (NK) lineage in an aged patient

Hematological Oncology
S KawanoO Koiwai

Abstract

A 66-year-old male patient was admitted with dyspnea; physical examination revealed petechiae and systemic lymphadenopathy. Laboratory findings showed leukemia. The blasts in the peripheral blood were negative for cytochemical myeloperoxidase, and had condensed nuclear chromatin with a nucleolus. The histological diagnosis of the biopsied neck lymph node was lymphoblastic lymphoma. The leukemia cells expressed CD2, CD6, CD7, CD13low, CD56, beta chain of IL-2 receptorlow (IL-2R beta), and HLA-DR antigens, but not other pan-T (CD5, CD3, CD4, and CD8); pan-B (CD10, CD19, CD20, and CD24); natural killer (NK) (CD16, CD57); or myeloid (CD33) antigens. Electronmicroscopy revealed convoluted nuclei with conspicuous nucleoli and peripherally condensed heterochromatin. Membrane-bound granules containing an electron dense matrix were observed in the cytoplasm, indicating the NK cell nature of the neoplastic cells. While terminal deoxynucleotidyl transferase (TdT) and cytoplasmic CD3 were not detected by immunofluorescence on fixed smears, Northern blot analysis revealed the gene expression of CD3 epsilon, CD3 zeta, and TdT. Gene rearrangement analysis revealed that the beta, gamma, and delta chains of T-cell receptor (TCR) and immunoglobu...Continue Reading

References

Aug 1, 1976·Cancer·B N NathwaniH Rappaport
Dec 1, 1988·The Journal of Experimental Medicine·E CicconeL Moretta
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A M WeissmanR D Klausner
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E Y LohL L Lanier
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M TsudoT A Waldmann
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·Y TakiharaT W Mak
Aug 1, 1986·American Journal of Hematology·J KaplanS Inoue
Apr 30, 1987·The New England Journal of Medicine·R E SobolD A Nelson
Apr 14, 1987·Biochemical and Biophysical Research Communications·O KoiwaiR Morishita
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K IkutaT Honjo
Dec 20, 1980·Nucleic Acids Research·N TakahashiT Honjo
Nov 1, 1982·European Journal of Immunology·D HuhnG Gastl
May 1, 1995·American Journal of Hematology·S KawanoF Nakamura
Oct 1, 1993·American Journal of Clinical Pathology·S KawanoN Yamaguchi

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Citations

Sep 2, 1998·Cancer Genetics and Cytogenetics·K SanoE Tatsumi
Aug 6, 2004·International Journal of Hematology·Yasushi OnishiKensei Tobinai
Sep 6, 2000·The British Journal of Dermatology·Y AmoK Katsuoka
Feb 15, 2001·Journal of the American Academy of Dermatology·N KatoT Nakata
Apr 3, 2001·American Journal of Hematology·E PaiettaUNKNOWN Eastern Cooperative Oncology Group
Sep 2, 2003·American Journal of Hematology·Michael ShapiroStephen J Schuster
Sep 26, 2003·The American Journal of Surgical Pathology·Kennosuke KarubeMasahiro Kikuchi
Jan 16, 2002·American Journal of Clinical Pathology·Michael G BayerlMargarita Palutke
Mar 7, 2001·Archives of Pathology & Laboratory Medicine·Y NatkunamP J Cornbleet

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