Novel localization of low affinity NGF receptor (p75) in the stroma of prostate cancer and possible implication in neoplastic invasion: an immunohistochemical and ultracytochemical study

The Prostate
Mario RendeEttore Mearini

Abstract

The localization of low affinity nerve growth factor receptor (p75) in prostate carcinogenesis is still unclear. Our aim was to reinvestigate the localization of p75 in normal and pathological prostate and to check a possible correlation to neoplastic grading. Specimens from 33 prostate cancers and from normal prostatic tissue were analyzed for p75 expression at light and ultrastructural levels. In normal tissue p75-immunoreactivity was restricted to basal cells in the epithelial compartment and to nerves and blood vessel in stroma. During carcinogenesis, p75-immunoreactivity progressively decreased at the periphery of the foci according to the increase in malignancy. No p75-immunoreactivity was detected inside of the foci. On the contrary, in stroma we found a dramatic increase in p75-immunoreactivity correlated to an increase in malignancy. In this compartment, for the first time ultrastructural analysis identified p75-immunoreactivity in smooth muscle cells (SMC) that are p75-negative in normal conditions. The present study confirms at ultrastructural level a malignant-dependent p75 decrease in basal cells of neoplastic foci. Furthermore, we show a novel, malignant-dependent localization of p75 in SMC in the stroma around th...Continue Reading

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Citations

Oct 19, 2011·Journal of Shoulder and Elbow Surgery·Yinghua XuGeorge A C Murrell
Sep 27, 2015·Biological Chemistry·Anna StabileMario Rende
Mar 3, 2017·Biological Chemistry·Claudia MontagnoliGiuliano G Cerulli
Sep 24, 2014·Molecular Cancer Research : MCR·Zuli YangJianping Wang
Feb 1, 2020·Theriogenology·Cesare CastelliniAlessandra Pistilli
Jan 15, 2021·Cancer Management and Research·Zhuo LiXiao-Ke Hao
Jan 1, 2011·Cancers·Niamh H MolloyAdrienne M Gorman

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