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Novel long-range regulatory mechanisms controlling PKD2 gene expression

BMC Genomics

Jul 11, 2018

Stéphanie MoisanClaude Férec

Abstract

Cis-regulatory elements control gene expression over large distances through the formation of chromatin loops, which allow contact between enhancers and gene promoters. Alterations in cis-acting regulatory systems could be linked to human genetic diseases. Here, we analyse the spatial o...read more

Mentioned in this Paper

Deoxyribonuclease I
PKD2 gene
Polycystic Kidney - Body Part
Genes
Regulation of Biological Process
CTCF
CCCTC-binding factor
Promoter
Kidney
TRPP Cation Channels
2
7
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Novel long-range regulatory mechanisms controlling PKD2 gene expression

BMC Genomics

Jul 11, 2018

Stéphanie MoisanClaude Férec

PMID: 29986647

DOI: 10.1186/s12864-018-4892-6

Abstract

Cis-regulatory elements control gene expression over large distances through the formation of chromatin loops, which allow contact between enhancers and gene promoters. Alterations in cis-acting regulatory systems could be linked to human genetic diseases. Here, we analyse the spatial o...read more

Mentioned in this Paper

Deoxyribonuclease I
PKD2 gene
Polycystic Kidney - Body Part
Genes
Regulation of Biological Process
CTCF
CCCTC-binding factor
Promoter
Kidney
TRPP Cation Channels
2
7

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Enhancers are short regions of the DNA which can be bound by activator or repressor proteins to affect transcription of a particular gene. This feed focuses on the role of enhancers in regulation of cell-type specific gene expression during development.

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