Novel markers of endothelial dysfunction and inflammation in Behçet's disease patients with ocular involvement: epicardial fat thickness, carotid intima media thickness, serum ADMA level, and neutrophil-to-lymphocyte ratio

Clinical Rheumatology
Murat YukselSait Alan

Abstract

The etiology of Behçet's disease (BD) has not been fully elucidated. However, immunological and environmental factors, endothelial dysfunction (ED), and genetic susceptibility have been proposed to play a role. In this study, we aimed to evaluate epicardial fat thickness (EFT) together with serum asymmetric dimethylarginine (ADMA), carotid intima media thickness (CIMT), and neutrophil-to-lymphocyte ratio (NLR) in BD patients with ocular involvement. Thirty-six ocular BD patients (17 active and 19 inactive ocular involvement), and 35 age and sex-matched healthy controls were enrolled to this cross-sectional study. All patients underwent examinations with transthoracic echocardiography and carotid Doppler ultrasound. Serum ADMA levels, CIMT, EFT, and NLR were compared between groups, and their association with disease activity was evaluated. Behçet's disease patients had higher WBC counts, neutrophil counts, NLR, CIMT, EFT values, and serum ADMA levels than do healthy controls. The other biochemical, hematological, and echocardiographic parameters were comparable between the two groups. Behçet's disease duration was positively correlated with EFT and CIMT. Multivariate logistic regression analysis revealed that increased serum AD...Continue Reading

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Citations

Apr 2, 2019·Scientific Reports·Gian Luca ErreAngelo Zinellu
Jul 12, 2017·Clinical Rheumatology·Seçil ConkarSevgi Mir
Oct 31, 2017·International Journal of Rheumatology·Fahd AdeebAlexander D Fraser
Sep 13, 2020·Clinical Rheumatology·Cheng-Cheng Hou, Jian-Long Guan
Nov 3, 2017·Rheumatology International·Rainer HintenbergerHerwig Pieringer
Jul 8, 2018·Clinical Rheumatology·Marwa HammadAmany Mohamed Mohiey El-Din

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