Novel mechanism of resistance to targeted therapies in lung cancer

Molecular & Cellular Oncology
Walter WangRajeswara Rao Arasada

Abstract

We have identified a non-canonical role of0 Notch3 in response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy, whereby Notch3 associates with β-catenin, resulting in increased catenin beta-1 (CTNNB1, best known as β-catenin) stability and increased survival of drug persister cells (DPCs). Furthermore, combined treatment of an EGFR TKI with a β-catenin inhibitor demonstrated improved therapeutic outcomes in xenograft models.

References

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Aug 12, 2018·Nature Communications·Rajeswara Rao ArasadaDavid P Carbone

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Citations

Aug 15, 2021·Molecular Cancer Research : MCR·Camille LeonceSandra Ortiz-Cuaran

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Methods Mentioned

BETA
co-immunoprecipitation
xenograft

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