Novel mechanisms in functional dyspepsia

World Journal of Gastroenterology : WJG
Rok Son Choung, Nicholas J Talley

Abstract

Functional dyspepsia (FD) is a highly prevalent but heterogeneous disorder in which multiple pathogenetic mechanisms are involved. Although there are many studies that have investigated various pathophysiologic mechanisms, the underlying casual pathways associated with FD remain obscure. The currently proposed pathophysiologic mechanisms associated with FD include genetic susceptibility, delayed as well as accelerated gastric emptying, visceral hypersensitivity to acid or mechanical distention, impaired gastric accommodation, abnormal fundic phasic contractions, abnormal antro-duodenal motility, acute and chronic infections, and psychosocial comorbidity. A greater understanding of the abnormalities underlying FD may lead to improved management. The aim of this editorial is to provide a critical overview of current pathophysiologic concepts in functional dyspepsia.

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Oct 21, 2006·Current Opinion in Gastroenterology·Mamie H Dong, Jonathan D Kaunitz
Nov 15, 2016·Gastroenterology Research and Practice·Wang-Ping MengMu-Han Lü
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Jan 1, 2014·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Masayuki Uchida, Chizuru Iwamoto
Apr 4, 2008·Journal of Clinical Biochemistry and Nutrition·Daisuke KaminoKazuaki Chayama
Jul 12, 2008·The American Journal of Gastroenterology·Nimish VakilMarielle Cohard-Radice

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