PMID: 11924715Apr 2, 2002Paper

Novel mechanisms of the antiproliferative effects of amlodipine in vascular smooth muscle cells from spontaneously hypertensive rats

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Yi-Mu LaiK Kanmatsuse

Abstract

The calcium channel blocker amlodipine continues to be of interest due to its potential proven ability to hinder the progression of atherosclerosis and reduce the number of clinical ischemic events. Vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) are useful in the study of atherosclerosis because they show exaggerated growth with production of angiotensin II (Ang II) by conversion to the synthetic phenotype. To clarify mechanisms of the antiproliferative effects of amlodipine, we evaluated effects of the expression of growth factors, the changes in phenotype, and the proliferation of VSMC from SHR. Amlodipine significantly inhibited basal DNA synthesis and proliferation of VSMC from SHR. Amlodipine also inhibited expression of platelet-derived growth factor (PDGF) A-chain, transforming growth factor beta1 (TGF-beta1) and basic fibroblast growth factor (bFGF) mRNAs in VSMC from SHR. Decreases in levels of PDGF A-chain and bFGF mRNAs in VSMC from SHR were greater with amlodipine than with nifedipine. Amlodipine significantly inhibited expression of the synthetic phenotype markers osteopontin and matrix Gla mRNAs, indicating that it inhibited the exaggerated growth of VSMC from SHR and suppressed the...Continue Reading

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Citations

May 26, 2012·Toxicology and Applied Pharmacology·Joshua K SalabeiDaniel J Conklin
Jul 10, 2010·Bioelectrochemistry·Rajendra N Goyal, Sunita Bishnoi
Apr 13, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Seiji UmemotoMasunori Matsuzaki
May 7, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuo YamagataMotoki Tagami
Oct 19, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masayuki UshiyamaShigehiro Katayama
Mar 24, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroshi AndoHiromasa Miyaji
Mar 5, 2004·Expert Opinion on Pharmacotherapy·J Wouter Jukema, José W A van der Hoorn
Oct 7, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rolf ZiescheLutz-Henning Block
Mar 31, 2019·British Journal of Pharmacology·Qin FangDao Wen Wang
Dec 25, 2002·Neurobiology of Aging·Bozena Mazur-KoleckaAdam Golabek

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