Novel mechanisms regulating endothelial barrier function in the pulmonary microcirculation

The Journal of Physiology
Szandor SimmonsW M Kuebler

Abstract

The pulmonary epithelial and vascular endothelial cell layers provide two sequential physical and immunological barriers that together form a semi-permeable interface and prevent alveolar and interstitial oedema formation. In this review, we focus specifically on the continuous endothelium of the pulmonary microvascular bed that warrants strict control of the exchange of gases, fluid, solutes and circulating cells between the plasma and the interstitial space. The present review provides an overview of emerging molecular mechanisms that permit constant transcellular exchange between the vascular and interstitial compartment, and cause, prevent or reverse lung endothelial barrier failure under experimental conditions, yet with a clinical perspective. Based on recent findings and at times seemingly conflicting results we discuss emerging paradigms of permeability regulation by altered ion transport as well as shifts in the homeostasis of sphingolipids, angiopoietins and prostaglandins.

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Citations

Mar 7, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Vitalii Kryvenko, István Vadász
May 21, 2020·Frontiers in Physiology·Tullio GenovaLuca Munaron
Jan 24, 2019·International Journal of Molecular Sciences·Angel CogolludoLaura Moreno
Feb 16, 2019·The Journal of Physiology·Larissa A Shimoda
Apr 15, 2020·Antioxidants & Redox Signaling·Mobarak Abu MraheilRudolf Lucas
Jan 14, 2021·DNA and Cell Biology·Maic Audo Eybi Mayer SihombingGuixue Wang
Feb 5, 2021·Blood·Simon J Cleary, Mark R Looney
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Apr 27, 2019·Immunobiology·Mohammad A UddinNektarios Barabutis
Apr 20, 2021·Intensive Care Medicine Experimental·Asbjørn G PetersenUlf Simonsen
May 1, 2021·Cells·Suhasini RajanAlexander Dietrich
Jun 25, 2021·Chemico-biological Interactions·Sahar M Jaffal, Manal A Abbas
Oct 11, 2020·Biochemical Pharmacology·Sonja RittchenAkos Heinemann

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