Novel Medical Treatments for Hypertension and Related Comorbidities

Current Hypertension Reports
Jared Davis, Suzanne Oparil

Abstract

The purpose of this review is to summarize the most recent data available on advances in development of novel medical treatments for hypertension and related comorbidities. Approximately half of all hypertensive patients have not achieved goal blood pressure with current available antihypertensive medications. Recent landmark studies and new hypertension guidelines have called for stricter blood pressure control, creating a need for better strategies for lowering blood pressure. This has led to a shift in focus, in recent years, to the development of combination pills as a means of achieving improved blood pressure control by increasing adherence to prescribed medications along with further research and development of promising novel drugs based on discovery of new molecular targets such as the counter-regulatory renin-angiotensin system. Fixed-dose combination pills and novel treatments based on recently discovered pathogenic mechanisms of hypertension that have demonstrated promising results as treatments for hypertension and related comorbidities will be discussed in this review.

References

Aug 29, 1974·The New England Journal of Medicine·S Oparil, E Haber
Aug 22, 1974·The New England Journal of Medicine·S Oparil, E Haber
Jun 28, 2003·BMJ : British Medical Journal·N J Wald, M R Law
Aug 7, 2007·The American Journal of Medicine·Sripal BangaloreFranz H Messerli
May 19, 2010·Hypertension·Silvia Quintão SavergniniRobson Augusto Souza Santos
Jul 24, 2010·The Journal of Biological Chemistry·Jérôme FagartPeter Kolkhof
Dec 17, 2010·Current Opinion in Pharmacology·Lie Gao, Irving H Zucker
Jul 21, 2011·Molecular and Cellular Endocrinology·Peter Kolkhof, Steffen A Borden
Sep 29, 2011·British Journal of Pharmacology·Alain Couvineau, Marc Laburthe
Apr 7, 2012·International Journal of Hypertension·Fúlvia D MarquesRobson A S Santos
Jul 28, 2012·Current Hypertension Reports·Sébastien FoulquierThomas Unger
Oct 31, 2012·Molecular and Cellular Biochemistry·Yogendra SinghP L Sharma
Dec 6, 2012·Current Hypertension Reports·Rodrigo Araujo Fraga-SilvaRobson Augusto Souza Dos Santos
Mar 1, 2013·Circulation Research·Roberto Queiroga LautnerRobson A S Santos
Jun 14, 2013·American Journal of Physiology. Renal Physiology·Gustavo Blanco, Darren P Wallace
Sep 5, 2013·JAMA : the Journal of the American Medical Association·Simon ThomUNKNOWN UMPIRE Collaborative Group
Jan 22, 2014·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Mar 14, 2014·Science Translational Medicine·Andrew G SpencerDominique Charmot
Jul 6, 2014·The American Journal of Cardiology·Steven G Chrysant, George S Chrysant
Jul 16, 2014·Peptides·Sérgio Henrique Sousa Santos, João Marcus Oliveira Andrade
Sep 2, 2014·The New England Journal of Medicine·John J V McMurrayUNKNOWN PARADIGM-HF Investigators and Committees
Oct 21, 2014·Journal of Bioequivalence & Bioavailability·Chris StockmannCatherine Mt Sherwin
Nov 19, 2014·Journal of the American Society of Nephrology : JASN·Eric D LabontéDominique Charmot

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Citations

Sep 13, 2019·International Journal of Hypertension·Pimphen CharoenChagriya Kitiyakara
Jan 20, 2021·Hypertension·Carlos M FerrarioLeanne Groban

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Clinical Trials Mentioned

NCT01873885
NCT01523067
NCT02808585

Software Mentioned

Polypill
Vasomera
FIRIBASTAT
HOPE
ARNI
NEW

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