Novel Metabolic Transformation Pathway for Cyclic Imides in Blastobacter sp. Strain A17p-4.

Applied and Environmental Microbiology
J OgawaS Shimizu

Abstract

The metabolic transformation pathway for cyclic imides in microorganisms was studied in Blastobacter sp. strain A17p-4. This novel pathway involves, in turn, hydrolytic ring opening of a cyclic imide to yield a monoamidated dicarboxylate, hydrolytic deamidation of the monoamidated dicarboxylate to yield a dicarboxylate, and dicarboxylate transformation similar to that in the tricarboxylic acid cycle. The initial step is catalyzed by a novel enzyme, imidase. Imidase and subsequent enzymes involved in this metabolic pathway are induced by some cyclic imides, such as succinimide and glutarimide. Induced cells metabolize various cyclic imides.

Citations

Jan 15, 1997·European Journal of Biochemistry·J OgawaS Shimizu
Feb 7, 1998·FEMS Microbiology Letters·C L SoongS Shimizu
Jan 7, 2014·Environmental Microbiology·Antoine Danchin, Agnieszka Sekowska
Sep 18, 2014·FEMS Microbiology Reviews·Víctor de LorenzoAntoine Danchin
Dec 19, 2001·The Journal of Biological Chemistry·Chee-Leong SoongSakayu Shimizu
Aug 9, 2013·Bioscience, Biotechnology, and Biochemistry·Makoto HibiJun Ogawa
Apr 21, 2011·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Zheng FanYiwei Liu
Apr 2, 1999·Applied and Environmental Microbiology·C L SoongS Shimizu
Nov 26, 2009·Archives of Biochemistry and Biophysics·Ya-Wei ShiXue-Yao Zhang

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