Novel methodology for assessing biomaterial-biofluid interaction in cancellous bone

Journal of the Mechanical Behavior of Biomedical Materials
Antony Bou-FrancisNikil Kapur

Abstract

Understanding the cement flow behaviour and accurately predicting the cement placement within the vertebral body is extremely challenging. Vertebral cancellous bone displays highly complex geometrical structures and architectural inhomogeneities over a range of length scales, thus making the scientific understanding of the cement injection behaviour difficult in clinical or cadaveric studies. Previous experimental studies on cement flow have used open-porous aluminum foam to represent osteoporotic bone. Although the porosity was well controlled, the geometrical structure of each of the foams was inherently unique. This paper presents novel methodology using customized, reproducible and pathologically representative three-dimensional bone surrogates to help study biomaterial--biofluid interaction. The aim was to provide a robust tool for comprehensive assessment of biomaterial injection behaviour through controlling the bone surrogate morphology and the injection parameters (i.e. needle gauge, needle placement, flow rate and injected volume), measuring the injection pressure, and allowing the visualization and quantitative analysis of the spreading distribution. This methodology provides a clinically relevant representation of c...Continue Reading

References

Feb 7, 1998·Spine·E R Myers, S E Wilson
Sep 1, 1999·Annals of Biomedical Engineering·E A NaumanT M Keaveny
May 17, 2001·Calcified Tissue International·J D Currey
Aug 7, 2003·Journal of Vascular and Interventional Radiology : JVIR·John M Mathis, Wade Wong
Sep 25, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Mary L Bouxsein
Apr 21, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Henry AhnCari Whyne
Oct 4, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E-M LochmüllerF Eckstein
Mar 12, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H ChenY Bunai
May 5, 2010·Neuroimaging Clinics of North America·Orlando Ortiz, John M Mathis
Nov 26, 2010·The Spine Journal : Official Journal of the North American Spine Society·Ran LadorJohn A Hipp
May 24, 2011·Journal of Biomechanical Engineering·René P Widmer, Stephen J Ferguson
Jan 20, 2012·The New England Journal of Medicine·Jean-Pierre Tourtier, Sophie Cottez
Mar 20, 2012·Heart & Lung : the Journal of Critical Care·Nicholas HabibKassem Harris
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
May 7, 2013·Journal of Neurosurgery. Spine·Gursukhman S SidhuAlexander R Vaccaro
Jul 23, 2013·Journal of the Mechanical Behavior of Biomedical Materials·René P Widmer SoykaStephen J Ferguson
Jun 11, 2014·Journal of Biomaterials Applications·Antony Bou-FrancisNikil Kapur

❮ Previous
Next ❯

Citations

Aug 5, 2017·Materials·Puneeth ShridharYoungJae Chun
Mar 5, 2021·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Tanguy VendeuvrePhilippe Rigoard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.