Novel methods of antiepileptic drug delivery -- polymer-based implants

Advanced Drug Delivery Reviews
Amy J HallidayMark J Cook

Abstract

Epilepsy is a neurological disorder characterised by spontaneous seizures. Over one third of patients receive insufficient benefit from oral anti-epileptic drug (AED) therapy, and continue to experience seizures whilst on medication. Epilepsy researchers are consequently seeking new ways to deliver AEDs directly to the seizure focus in the brain in order to deliver higher, more effective doses to the seizure focus whilst bypassing the remainder of the brain and body to prevent side effects. The focus of this review will be polymer-based implants, which are polymeric devices loaded with AED that are designed for implantation at the seizure focus in order to achieve gradual, continuous release of AED direct into the region of the brain responsible for seizures. Polymer-based implants produced for epilepsy to date are based on a range of polymers, both biodegradable and non-biodegradable, and range from simple materials development studies through to investigations of implants in animal models of seizures and epilepsy, with varying degrees of success. This review describes the range of methods employed to manufacture polymer-based implants and compares their advantages and potential appeal to industry, and describes and compares t...Continue Reading

References

Mar 1, 1977·Journal of the Neurological Sciences·D H AdamsH M Wiśniewski
Feb 1, 1989·Electroencephalography and Clinical Neurophysiology·S BrailowskyR Naquet
Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y I JeongC S Cho
Apr 9, 1999·Drug Development and Industrial Pharmacy·J M BarichelloT Nagai
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·L MontanariB Conti
Feb 12, 2002·Journal of Microencapsulation·J Chen, S S Davis
Mar 2, 2002·Science·I G LoscertalesA M Gañán-Calvo
Mar 29, 2002·Journal of Pharmaceutical Sciences·Nadia PasseriniLorenzo Rodriguez
Aug 3, 2002·CNS Drugs·Robert S Fisher, Jet Ho
Aug 23, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jörg Breitenbach
Sep 11, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yu Liu, Xianmo Deng
Feb 5, 2003·Seizure : the Journal of the British Epilepsy Association·Henrik KlitgaardDoru-Georg Margineanu
Aug 9, 2003·The Journal of Pharmacy and Pharmacology·Jelena Filipović-GrcićIvan Jalsenjak
Oct 22, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jing ZengXiabin Jing
Dec 31, 2003·International Journal of Pharmaceutics·S Haznedar, B Dortunç
Jun 11, 2005·Epilepsia·Dieter Schmidt, Wolfgang Löscher
Nov 1, 2005·International Journal of Pharmaceutics·E GaviniP Giunchedi
Dec 24, 2005·Nature Reviews. Neuroscience·N Joan AbbottElisabeth Hansson
Jan 21, 2006·Drug Delivery·Nahla S Barakat, Alaa Eldeen B Yassin
Aug 31, 2006·Biotechnology Journal·Thomas BolandXiaofeng Cui
Oct 24, 2006·International Journal of Pharmaceutics·Ana Rita C DuartePascale Subra-Paternault
Nov 4, 2006·International Journal of Pharmaceutics·W Y DongR Bodmeier
Nov 23, 2006·Epilepsia·Emily Oby, Damir Janigro
Dec 5, 2006·Journal of Materials Science. Materials in Medicine·Petrus ViitanenNureddin Ashammakhi
Jan 25, 2008·Drug Development and Industrial Pharmacy·James E PattersonThomas Rades
May 2, 2008·International Journal of Pharmaceutics·Neeraj SivadasSally-Ann Cryan
Jun 3, 2008·Biomaterials·Andrew WilzDetlev Boison
Aug 16, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Changhong ZhangThomas Boland
May 23, 2009·Experimental Neurology·Cory SzybalaDetlev Boison
Jul 16, 2009·CNS & Neurological Disorders Drug Targets·A J Halliday, M J Cook
Feb 9, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Eleanor M PritchardDavid L Kaplan
Mar 17, 2010·International Journal of Pharmaceutics·Sandeep Kumar TiwariSubbu S Venkatraman

❮ Previous
Next ❯

Citations

Jun 25, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ammar ArsiwalaVandana Patravale
Dec 3, 2015·Drug Development and Industrial Pharmacy·Leena Kumari Prasad, Hugh Smyth
Nov 6, 2012·Artificial Intelligence in Medicine·Marie ChanEric Campo
Oct 21, 2015·Restorative Neurology and Neuroscience·Jonathan L JiangMark J Cook
Jul 6, 2014·Neuroscience·Y WuZ Song
Dec 6, 2016·Macromolecular Bioscience·Sebastien H BauquierMark J Cook
Dec 4, 2016·Journal of Biomaterials Applications·Liciane Sabadin BertolLuís Alberto Loureiro Dos Santos
Sep 13, 2017·Biomaterials Science·Yu ChenGordon G Wallace
Sep 1, 2018·Expert Opinion on Drug Delivery·Gilles Sebastiaan van TienderenGordon G Wallace
Dec 2, 2020·Pharmaceutics·Manuela Gernert, Malte Feja
Feb 6, 2021·Pharmaceutics·Anna FroelichBozena Michniak-Kohn
Apr 28, 2018·ACS Applied Materials & Interfaces·Yuxiao LiuYuanjin Zhao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.