Novel microcomposite implant for the controlled delivery of antibiotics in the treatment of osteomyelitis following total joint replacement.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Serkan InceogluVictoria K Maskiewicz

Abstract

The objective of this study was to develop a novel microcomposite implant to be used in the treatment of osteomyelitis following total joint arthroplasty, with the dual purpose of releasing high local concentrations of antibiotic to eradicate the infection while providing adequate mechanical strength to maintain the dynamic or static spacer. Vancomycin-loaded microcomposite implants were fabricated by incorporating drug-loaded microparticles comprised of mesoporous silica into commonly employed polymethylmethacrylate (PMMA) bone cement, to yield a final drug loading of 10% w/w. In vitro release kinetics at 37°C were monitored by reverse-phase high-performance liquid chromatography, and compared to the release kinetics of current therapy implants consisting of drug alone incorporated at 10% w/w directly into PMMA bone cement. Results demonstrated a sevenfold improvement in the elution profile of microcomposite systems over current therapy implants. In vivo delivery of vancomycin to bone from microcomposite implants (70% of payload) was significantly higher than that from current therapy implants (approx. 22% of payload) and maintained significantly higher bone concentrations for up to 2 weeks duration. The elastic modulus showed...Continue Reading

References

Nov 1, 1976·Journal of Biomedical Materials Research·E P LautenschlagerP R Meyer
Oct 1, 1990·Antimicrobial Agents and Chemotherapy·W E PeetermansH Mattie
Jan 1, 1989·Journal of Biomechanics·A OdgaardF Linde
Jan 1, 1980·Archives of Orthopaedic and Trauma Surgery·A RohlmannR Kölbel
Dec 15, 1996·Structure·M SchäferG M Sheldrick
Nov 21, 2000·International Journal of Pharmaceutics·P Frutos CabanillasG Frutos
Jan 6, 2001·Acta Orthopaedica Scandinavica·H van de BeltH J Busscher
Mar 10, 2001·Journal of Biomedical Materials Research·W A HiggsM V Swain
Nov 6, 2002·Journal of Biomedical Materials Research·Y HeJ Verdu
Apr 9, 2004·The New England Journal of Medicine·Rabih O Darouiche
May 19, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·A L DoadrioM Vallet-Regí
Sep 16, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Gladius Lewis, Si Janna
Oct 16, 2004·The New England Journal of Medicine·Werner ZimmerliPeter E Ochsner
Dec 15, 2005·The International Journal of Artificial Organs·C R ArciolaL Montanaro
Aug 15, 2006·Clinical Orthopaedics and Related Research·Alex C McLarenMark Smeltzer
Jun 19, 2007·Clinical Orthopaedics and Related Research·Valentin AntociJavad Parvizi
Sep 1, 2007·Clinical Orthopaedics and Related Research·A C McLarenB L Vernon
Sep 15, 2007·Angewandte Chemie·María Vallet-RegíDaniel Arcos
Apr 19, 2008·Clinical Orthopaedics and Related Research·Luis PulidoJavad Parvizi
May 22, 2008·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·N J DunneM Tunney
Jun 7, 2008·The Journal of Arthroplasty·Matthew H PelletierWilliam R Walsh
Jun 7, 2008·The Journal of Arthroplasty·Massimiliano BaleaniDomenico Tigani
Oct 1, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Gladius Lewis
Nov 6, 2008·Journal of Molecular Biology·Patrick J LollPaul H Axelsen
Sep 17, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Sebastiano LeoneUNKNOWN GISIG (Gruppo Italiano di Studio sulle Infezioni Gravi) Working Group on Prosthetic Joint Infections
May 14, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Christopher R RathboneJoseph C Wenke
Jul 26, 2011·Journal of Materials Science. Materials in Medicine·Shou-Cang ShenReginald Beng Hee Tan
Dec 14, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ji-Le JiangJian Dong
Oct 25, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Morgan B GiersRyan McLemore
Nov 12, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Josh SlaneMatthew Squire
Jun 10, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Josh SlaneHeidi-Lynn Ploeg
Jan 1, 2016·Arthroplasty Today·Bryan D Springer, Caryn D Etkin
Apr 13, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Edward M SchwarzBrian Winters
Nov 7, 2019·The Journal of the American Academy of Orthopaedic Surgeons·Paul F LachiewiczJonathan R Peterson

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