Novel missense mutation in WNT6 in 100 couples with unexplained recurrent miscarriage

Human Reproduction
Yimei ZhangZi-Jiang Chen

Abstract

Do mutations and/or polymorphisms in coding sequences in Wingless-Type MMTV Integration Site Family, Member 6 (WNT6) play a role in unexplained recurrent miscarriage (unexplained RM) in Chinese couples? We found four mutations in the coding sequences of WNT6 which appear to exist in a small proportion of Chinese women with unexplained RM. WNT6 has been proved to be essential for stromal cell proliferation during decidualization in mice, but in humans WNT6 has not been studied in recurrent miscarriage populations. For this study, 100 couples with unexplained RM (at least three or more unexplained spontaneous miscarriages), and 100 ethnically matched fertile couples (at least one live birth and no history of pregnancy pathologies) were recruited. All the participants were chosen over a 7-year period from the National Research Center for Assisted Reproductive Technology and Reproductive Genetics at Shandong University, Jinan, China. Patients were recruited following extensive clinical studies. Genomic DNA was isolated from peripheral blood. Mutation analysis in the coding regions of WNT6 was performed by PCR amplification and DNA sequences testing in all participants. Functional effects of missense variants were predicted using Po...Continue Reading

References

Feb 7, 1998·Genes & Development·K M Cadigan, R Nusse
Aug 15, 2002·Mechanisms of Development·Frank R SchubertSusanne Dietrich
Jun 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Othman A MohamedDaniel Dufort
Feb 2, 2006·The Journal of Clinical Endocrinology and Metabolism·Suzana TulacLinda C Giudice
Oct 26, 2007·Seminars in Reproductive Medicine·Birgit GellersenJan J Brosens
Jan 24, 2009·Biology of Reproduction·Kanako HayashiThomas E Spencer
Feb 17, 2009·Developmental Biology·Tobias LengfeldThomas W Holstein
Feb 19, 2009·Molecular Human Reproduction·Qi ChenEnkui Duan
Jul 22, 2009·Developmental Cell·Bryan T MacDonaldXi He
Jul 14, 2011·Development·Jenifer CroceDavid R McClay
Sep 10, 2011·Basic & Clinical Pharmacology & Toxicology·Maurizio Mandala, George Osol
Dec 20, 2011·Fertility and Sterility·Yujie DangZi-Jiang Chen
Nov 24, 2012·Biology of Reproduction·Qiang WangHaibin Wang
Jun 28, 2013·BMC Medicine·Elisabeth Clare LarsenNick Macklon
Aug 15, 2013·Obstetrical & Gynecological Survey·Jaume Alijotas-Reig, Carmen Garrido-Gimenez

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Citations

Jun 1, 2019·Human Reproduction Update·Emily ColleyStephanie Allen
Feb 4, 2021·Biology of Reproduction·Yaoming PengCongjian Xu

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