Novel Molecular Leads for the Prevention of Damage and the Promotion of Repair in Neuroimmunological Disease

Frontiers in Immunology
Mahshad KolahdouzanLuke M Healy

Abstract

Neuroinflammation is a prominent pathological feature of all neuroimmunological diseases, including, but not limited to, multiple sclerosis (MS), myasthenia gravis, neuromyelitis optica, and Guillain-Barré syndrome. All currently-approved therapies for the treatment of these diseases focus on controlling or modulating the immune (innate and adaptive) responses to limit demyelination and neuronal damage. The primary purpose of this review is to detail the pre-clinical data and proposed mechanism of action of novel drugs currently in clinical trial, with a focus on novel compounds that promote repair and regeneration in the central nervous system (CNS). As the most recent advances have been made in the field of MS research, this review will focus primarily on this disease and its animal models. However, these compounds are likely to be effective for a range of indications with a neuroinflammatory component. Traditionally, MS was thought to proceed through two distinct phases. The first, predominantly inflammatory stage, is characterized by acute episodes of clinical relapse, followed by periods of partial or total recovery with an apparent absence of overall disease progression. In the vast majority of patients, this relapsing-re...Continue Reading

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Citations

Mar 18, 2020·Journal of Leukocyte Biology·Martin W Lo, Trent M Woodruff
Apr 18, 2020·Expert Opinion on Investigational Drugs·Pablo Villoslada, Lawrence Steinman
Nov 27, 2020·Frontiers in Immunology·Sameera ZiaJason R Plemel
May 8, 2021·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Mark B Skeen

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Methods Mentioned

BETA
electron microscopy

Clinical Trials Mentioned

NCT02149706
NCT02398461
NCT02040298
NCT01721161
NCT03222973
NCT02936037
NCT02220244

Software Mentioned

ReBuild
Principa

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