Novel molecular mechanisms and regeneration therapy for heart failure

Journal of Molecular and Cellular Cardiology
Toru OkaIssei Komuro

Abstract

Heart failure (HF) is one of the leading causes of mortality in the world. Various molecular mechanisms have been proposed for HF, but its precise mechanisms are still largely unknown. In this review, summarizing the "President's Distinguished Lecture Award" of XX World Congress of International Society for Heart Research 2010 in Kyoto, Japan, we introduce recent our studies on HF, including 1) p53-induced suppression of Hif-1-induced angiogenesis as a novel mechanism of HF, 2) angiogenesis as a potential therapeutic strategy for HF, and 3) IGFBP-4 as a novel factor for cardiomyogenesis by inhibiting canonical Wnt signaling.

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Citations

Oct 30, 2018·Journal of Cellular Physiology·Che WangChuanyu Gao
Aug 20, 2019·Journal of Cardiovascular Pharmacology·Heng Zeng, Jian-Xiong Chen
Aug 31, 2016·European Journal of Clinical Investigation·Rosa María AgraJohn P H Wilding
Feb 16, 2021·Journal of the American Heart Association·Lanfang LiJian-Xiong Chen
Mar 26, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiao-Lei MaHui-Hua Li

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