Novel molecular targets in the treatment of systemic lupus erythematosus

Autoimmunity Reviews
José C Crispín, George C Tsokos

Abstract

T cells from patients with systemic lupus erythematosus (SLE) display a number of biochemical abnormalities which include altered expression of key signaling molecules, heightened calcium responses, and skewed expression of transcription factors. These defects are involved in the altered behavior of SLE T cells and are probably central in the disease pathogenesis. The aim of this communication is to review the defects that have been consistently documented in SLE T cells, highlighting molecules and pathways that represent therapeutic targets.

References

Jun 1, 1982·The Journal of Clinical Investigation·J Alcocer-Varela, D Alarcón-Segovia
May 25, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Thomas M HerndonGeorge C Tsokos
May 10, 2003·Trends in Immunology·George C TsokosYuang-Taung Juang
Aug 12, 2005·Current Opinion in Rheumatology·Vasileios C KyttarisGeorge C Tsokos
Oct 15, 2005·The Journal of Clinical Investigation·Christina G KatsiariGeorge C Tsokos
Oct 28, 2005·Journal of Medicinal Chemistry·Steven D LintonCheng-zhi Zhang
Jan 25, 2006·Autoimmunity Reviews·Christina G Katsiari, George C Tsokos
May 23, 2006·Journal of Autoimmunity·Naim Akhtar KhanAziz Hichami
May 23, 2006·Seminars in Immunology·Sandeep KrishnanGeorge C Tsokos
Aug 8, 2006·Autoimmunity Reviews·Clive H Wasserfall, Mark A Atkinson
Aug 22, 2006·Autoimmunity Reviews·Mauro GaleazziGian Domenico Sebastiani
Sep 26, 2006·Journal of Autoimmunity·Marit BjørnvoldDag E Undlien
Oct 10, 2006·Autoimmunity Reviews·Raul N Mandler
Oct 21, 2006·Journal of Autoimmunity·Amy E WandstratNancy J Olsen
Nov 18, 2006·Autoimmunity Reviews·Yrjö T KonttinenPraseet Poduval
Nov 18, 2006·Autoimmunity Reviews·Jozef Rovenský
Dec 2, 2006·Autoimmunity Reviews·Ronald A Asherson
Dec 2, 2006·Autoimmunity Reviews·W MiesbachUNKNOWN Members of CAPS Registry Group
Dec 2, 2006·Autoimmunity Reviews·Laurence C Eisenlohr, Jay L Rothstein
Jun 1, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Polly R PineErnest Brahn

❮ Previous
Next ❯

Citations

Jan 6, 2010·Rheumatology International·Anna KozłowskaPaweł Piotr Jagodziński
Jan 10, 2012·Journal of Clinical Immunology·Monika EdelbauerElisabeth Steichen-Gersdorf
Oct 15, 2009·Molecular Biology Reports·Teresa WarchołPaweł P Jagodziński
Jun 26, 2012·Molecular Biology Reports·Piotr PiotrowskiPaweł P Jagodziński
Dec 18, 2008·Clinical Reviews in Allergy & Immunology·Jennifer L LeeM Eric Gershwin
Jul 14, 2009·Arthritis Research & Therapy·Fanny Monneaux, Sylviane Muller
May 28, 2010·Stem Cell Research & Therapy·Takayoshi YamazaSongtao Shi
Feb 11, 2015·Modern Rheumatology·Piotr PiotrowskiPaweł P Jagodziński
Jul 10, 2014·Expert Opinion on Biological Therapy·Alberta Hoi, Geoff Littlejohn
Aug 3, 2010·Journal of Autoimmunity·Pierre Youinou
Apr 15, 2010·Autoimmunity Reviews·Bruno GualanoClovis Artur Almeida Silva
Aug 30, 2008·Autoimmunity Reviews·José C Crispín, George C Tsokos
Aug 30, 2008·Autoimmunity Reviews·Kui Liu, Chandra Mohan
Mar 17, 2010·Tissue Antigens·P PiotrowskiP P Jagodziński
Jun 19, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Weiguo SuiYong Dai
Aug 22, 2013·Lupus·P Grech, Ma Khamashta
Dec 4, 2009·The Journal of Rheumatology·Anna KozlowskaPawel P Jagodzinski
Oct 21, 2017·Oncotarget·Shujie ZhangYouhua Xie
May 21, 2011·Molecular Biology Reports·Piotr PiotrowskiPaweł P Jagodziński
Jan 1, 2014·Journal of Immunology Research·Guang-ping RuanXing-hua Pan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Related Papers

Journal of Autoimmunity
Margaret A Jordan, Alan G Baxter
Journal of Autoimmunity
Pietro Invernizzi, M Eric Gershwin
© 2021 Meta ULC. All rights reserved