Novel monoamine oxidase A knock out mice with human-like spontaneous mutation.

Neuroreport
Anna L ScottJean C Shih

Abstract

A novel line of mutant mice [monoamine oxidase A knockout (MAOA KO)] harboring a spontaneous point nonsense mutation in exon 8 of the MAO A gene was serendipitously identified in a 129/SvEvTac colony. This mutation is analogous to the cause of a rare human disorder, Brunner syndrome, characterized by complete MAO A deficiency and impulsive aggressiveness. Concurrent with previous studies of MAO A KO mice generated by insertional mutagenesis ('Tg8'), MAOA(A863T) KO lack MAO A enzyme activity and display enhanced aggression toward intruder mice. MAOA(A863T) KO, however, exhibited lower locomotor activity in a novel, inescapable open field and similar immobility during tail suspension compared with wild type, observations which differ from reports of Tg8. These findings consolidate evidence linking MAO A to aggression and highlight subtle yet distinctive phenotypical characteristics.

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Citations

Apr 23, 2013·Cell and Tissue Research·Laura M HuckinsGabriela Sánchez-Andrade
Mar 2, 2011·Journal of Neural Transmission·Jean C ShihKevin Chen
May 25, 2011·Journal of Neural Transmission·Zhi-qiang WangJean C Shih
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