Novel MRI method to detect altered left ventricular ejection and filling patterns in rodent models of disease.

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Daniel J StuckeyK Clarke

Abstract

The aim of this study was to determine whether high-temporal-resolution (HTR) cardiac cine-MRI could be used to identify subtle alterations in contractility and diastolic function in rodent models of disease. Following standard 45-min in vivo MRI measurements of left ventricular (LV) volumes, a single mid-ventricular slice was selected for 3-min HTR imaging. Cavity volume was measured every 2.4 ms, yielding approximately 60 images through the cardiac cycle. From these images, peak ejection and filling rates were calculated and two separate filling phases (comparable with the early (E) and late (A) phases of a Doppler echocardiogram) were identified during diastole. Repeated HTR imaging of the same animals on sequential days indicated reproducibility of E'/A' ratios of 11%. In chronically infarcted rat hearts, HTR imaging revealed lower peak ejection rates (PERs), peak early filling rates (E') and E'/A' ratios, and higher peak late filling rates (A') than in sham-operated rats. Diabetic db/db mouse hearts had the same function as controls when using standard cine-MRI, yet HTR imaging identified significantly lower PERs, early filling rates and E'/A' ratios in diabetic mouse hearts. In conclusion, the HTR MRI technique revealed c...Continue Reading

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Citations

May 18, 2012·Cardiovascular Research·Michael S DoddDamian J Tyler
Mar 17, 2010·American Journal of Physiology. Heart and Circulatory Physiology·G BubP Kohl
Aug 5, 2011·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Daniel J StuckeyKieran Clarke
Oct 29, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Behzad EbrahimiLilach O Lerman
Dec 20, 2013·Stem Cells and Development·Lien-Cheng HsiaoCarolyn A Carr
Jul 6, 2011·Journal of Neuroscience Methods·Patrick C HettingerJames S Hyde
Jul 6, 2010·Journal of Molecular and Cellular Cardiology·Weihua SongSteven Marston
Oct 22, 2008·Journal of Molecular and Cellular Cardiology·Wen ZhangKieran Clarke
Aug 19, 2015·Progress in Nuclear Magnetic Resonance Spectroscopy·Adrianus J BakermansKlaas Nicolay
Oct 31, 2012·NMR in Biomedicine·Abdallah G MotaalGustav J Strijkers
Apr 21, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Bram F CoolenGustav J Strijkers
May 20, 2015·Nature Communications·Michela NosedaMichael D Schneider
Aug 18, 2012·Theriogenology·A P StephensonS A Williams
Dec 22, 2016·International Journal of Molecular Sciences·Maximilian E HölscherHeiko Bugger
Jan 31, 2018·International Journal of Genomics·Jing HanYan Wu
Jan 16, 2014·Circulation. Cardiovascular Imaging·Daniel J StuckeyMichael D Schneider
Sep 23, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Sander LandNicolas P Smith
Nov 10, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Ikeotunye Royal ChinyereSteven Goldman
Aug 23, 2017·The American Journal of Pathology·Ravneet VohraGlenn A Walter
Sep 4, 2009·Disease Models & Mechanisms·Heiko Bugger, E Dale Abel
Apr 29, 2020·The American Journal of Pathology·Natalie A NollW David Merryman

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