Novel MUC1 splice variants are expressed in cervical carcinoma

Gynecologic Oncology
Andreas ObermairRobert Zeillinger

Abstract

The MUC1 antigen can be used to identify epithelial cells from the background of hemopoietic cells. The present investigation describes patterns of overexpression of two novel MUC1 splice variants in human cervical carcinoma cell lines. RT-PCR was carried out to determine MUC1 splice variants in the cervical cancer cell lines C-4 II, C-33A, DoTc 2 4510, C-4 I, SiHa, HT3, Hs 636 T (C4-I), and HeLa. The novel MUC1 splice variant D was expressed in all cell lines and the novel MUC1 splice variant C was expressed in all cell lines but C-33A. Variants A and B were expressed in all (variant A) and all but one (variant B) cell line. MUC1/REP was expressed in all cell lines and MUC1/SEC was positive in all but two cell lines (C-33 A, DoTc 2 4510). All but one cell line (C-33A) expressed MUC1/X and MUC1/Y, and two cell lines (C-33 A, DoTc 2 4510) did not express MUC1/Z, respectively. MUC1 variants A, D, and REP could be demonstrated consistently among all eight cervical carcinoma cell lines we have examined. The present study describes the feasibility of detecting a large number of MUC1 variants, including MUC1 variants C and D which are described for cervical carcinoma cells for the first time. Further studies will examine the presence...Continue Reading

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Citations

Mar 29, 2014·Trends in Molecular Medicine·Sritama Nath, Pinku Mukherjee
Aug 22, 2015·Cellular and Molecular Life Sciences : CMLS·Vasso ApostolopoulosSharron E Gargosky
Aug 20, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Andreia M SousaFilipe Santos-Silva
Jan 5, 2017·Journal of Innate Immunity·Jos P M van Putten, Karin Strijbis
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Andreas ObermairRobert Zeillinger
Feb 25, 2009·British Journal of Cancer·W NgD M Swallow
Jul 1, 2005·The Journal of Biological Chemistry·Fiana LevitinDaniel H Wreschner
Jun 2, 2006·The Journal of Biological Chemistry·Nicolas MoniauxSurinder K Batra
Jan 17, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·A Marina Hinojosa-KurtzbergSandra J Gendler
Dec 30, 2004·The Journal of Biological Chemistry·Fiana LevitinDaniel H Wreschner
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph F GrossoDiana M Lopez
May 20, 2015·The International Journal of Biological Markers·Martin E RabassaMaria Virginia Croce

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