Novel Mutation in Cytochrome B of Plasmodium falciparum in One of Two Atovaquone-Proguanil Treatment Failures in Travelers Returning From Same Site in Nigeria

Open Forum Infectious Diseases
Mateusz M PlucinskiJohn W Barnwell

Abstract

Atovaquone-proguanil (AP) is the most commonly used treatment for uncomplicated Plasmodium falciparum malaria in the United States. Apparent AP treatment failures were reported 7 months apart in 2 American travelers who stayed in the same compound for foreign workers in Rivers State, Nigeria. We analyzed pretreatment (day 0) and day of failure samples from both travelers for mutations in the P falciparum cytochrome B (pfcytb) and dihydrofolate reductase (pfdhfr) genes associated with resistance to atovaquone and cycloguanil, the active metabolite of proguanil, respectively. We genotyped the parasites and sequenced their mitochondrial genomes. On day 0, both travelers had proguanil-resistant genotypes but atovaquone-sensitive cytb sequences. Day of failure samples exhibited mutations in cytb for both travelers. One traveler had the common Y268S mutation, whereas the other traveler had a previously unreported mutation, I258M. The travelers had unrelated parasite genotypes and different mitochondrial genomes. Despite the infections likely having been contracted in the same site, there is no evidence that the cases were related. The mutations likely arose independently during the acute infection or treatment. Our results highlight ...Continue Reading

References

Dec 1, 1995·The Journal of Antimicrobial Chemotherapy·P L ChiodiniD A Warrell
May 29, 1999·Antimicrobial Agents and Chemotherapy·I K Srivastava, A B Vaidya
Apr 9, 2002·The Lancet Infectious Diseases·Chansuda WongsrichanalaiSteven R Meshnick
Sep 17, 2002·The Journal of Infectious Diseases·Joseph F CorteseChristopher V Plowe
Mar 19, 2003·Proceedings. Biological Sciences·N J White, W Pongtavornpinyo
Jul 2, 2003·Molecular Biology and Evolution·Shalini NairTim J C Anderson
Jul 29, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eli SchwartzKevin C Kain
Oct 13, 2004·The Journal of Infectious Diseases·Ole WichmannUNKNOWN European Network on Surveillance of Imported Infectious Diseases
May 13, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·A BerryJ F Magnaval
Dec 19, 2007·Malaria Journal·Marie-Thérèse EkalaOdile Mercereau-Puijalon
Feb 9, 2008·Emerging Infectious Diseases·Rémy DurandJacques Le Bras
Apr 25, 2008·The Pediatric Infectious Disease Journal·Gregory W RoseAnne E McCarthy
Dec 7, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Regina C LaRocqueUNKNOWN Global TravEpiNet Consortium
Jan 4, 2012·Malaria Journal·Viera SvihrovaHenrieta Hudeckova
Apr 27, 2013·Chest·Earl S FordWayne H Giles
Sep 14, 2013·Trends in Parasitology·Inbarani Naidoo, Cally Roper

❮ Previous
Next ❯

Citations

Mar 5, 2016·MMWR. Surveillance Summaries : Morbidity and Mortality Weekly Report. Surveillance Summaries·Karen A CullenUNKNOWN Centers for Disease Control and Prevention (CDC)
Oct 30, 2016·Trends in Parasitology·Christopher D GoodmanGeoffrey I McFadden
Feb 10, 2017·Trends in Parasitology·Sarah K VolkmanDaniel L Hartl
Dec 14, 2017·The Journal of Antimicrobial Chemotherapy·Henry M StainesSanjeev Krishna
Sep 22, 2017·Journal of Travel Medicine·Anna A MintaPaul M Arguin
Mar 24, 2016·Antimicrobial Agents and Chemotherapy·Eldin TalundzicVenkatachalam Udhayakumar
Jun 9, 2016·Antimicrobial Agents and Chemotherapy·Allison M SticklesMichael K Riscoe
May 31, 2018·Proceedings of the National Academy of Sciences of the United States of America·Kristin D LaneThomas E Wellems
Feb 15, 2018·Antimicrobial Agents and Chemotherapy·Eldin TalundzicVenkatachalam Udhayakumar
May 4, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Mariangela L'EpiscopiaCarlo Severini

❮ Previous
Next ❯

Datasets Mentioned

BETA
KM065500

Methods Mentioned

BETA
PCR
genotyping

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.